Detailed information of TA system TA026761

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 931098..931710
• Replicon: chromosome
• Accession: NC_017371
• Organism: Helicobacter pylori Gambia94/24 (Helicobacter pylori Gam94/24)

Toxin (Protein)

• Gene name: relE
• Uniprot ID: E8QHZ3
• Locus tag: HPGAM_RS04455
• Protein ID: WP_014535981.1
• Coordinates: 931098..931364 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: E8QHZ4
• Locus tag: HPGAM_RS04460
• Protein ID: WP_001134108.1
• Coordinates: 931345..931710 (-)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPGAM_RS04415	926342..927322	-	981	WP_000921457.1	iron ABC transporter permease	-
HPGAM_RS04420	927315..928172	-	858	WP_000538064.1	SDR family oxidoreductase	-
HPGAM_RS04425	928312..928836	+	525	WP_001135600.1	acyl-CoA thioesterase	-
HPGAM_RS04430	928880..929212	-	333	WP_000889636.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
HPGAM_RS04435	929221..929503	-	283	Protein_862	hypothetical protein	-
HPGAM_RS04440	930074..930433	-	360	WP_001134109.1	hypothetical protein	-
HPGAM_RS04445	930481..930749	-	269	Protein_864	type II toxin-antitoxin system mRNA interferase toxin, HP0892 family	-
HPGAM_RS04450	930763..931050	-	288	WP_001134116.1	type II toxin-antitoxin system antitoxin	-
HPGAM_RS04455	931098..931364	-	267	WP_014535981.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HPGAM_RS04460	931345..931710	-	366	WP_001134108.1	hypothetical protein	Antitoxin
HPGAM_RS04465	932599..934839	-	2241	WP_000716288.1	Hop family adhesin BabA	-
HPGAM_RS08410	935851..936126	-	276	WP_014535982.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10341.30 Da
• Isoelectric Point: 8.0521

>T26761 WP_014535981.1 NC_017371:c931364-931098 [Helicobacter pylori Gambia94/24]
VLKLNLKESFQKDFDKLLLNGFDDSVLKEVILTLRKKEPLPPPFKDHALKGIWKPYRECHIKLDILLVYLVKDDELILLR
LGSHSELF

Nucleotide

• Length: 267 bp

>T26761 NC_017371:c931364-931098 [Helicobacter pylori Gambia94/24]
GTGTTGAAGCTCAATCTTAAAGAATCTTTTCAAAAAGATTTTGATAAATTGCTTTTGAATGGGTTTGATGATAGCGTTTT
GAAGGAAGTCATTCTAACCTTAAGAAAGAAAGAACCGCTACCCCCACCATTTAAAGATCACGCTTTAAAGGGGATTTGGA
AGCCTTATAGAGAATGCCACATTAAGCTTGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAACTGATTTTGTTAAGG
CTAGGCAGTCATAGCGAGTTGTTTTGA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 14373.31 Da
• Isoelectric Point: 8.9643

>AT26761 WP_001134108.1 NC_017371:c931710-931345 [Helicobacter pylori Gambia94/24]
MPNTTKKDYTKYSQRQLFNLMNKKEQEIEKLKRDRAYLEKKMAKELEKKDKGFTIKLEELNKILQEINKRANDCCFGHET
PNIQTQQAMRETDNKETDLFVEDFSSYSNERKKALGVEAQS

Nucleotide

• Length: 366 bp

>AT26761 NC_017371:c931710-931345 [Helicobacter pylori Gambia94/24]
ATGCCAAACACCACCAAAAAAGATTACACAAAATACAGCCAAAGACAGCTTTTTAATCTCATGAATAAAAAAGAACAAGA
AATTGAAAAGCTAAAAAGGGATAGGGCGTATCTTGAAAAGAAAATGGCTAAAGAGCTAGAAAAAAAAGATAAAGGTTTCA
CTATCAAGTTAGAAGAATTGAACAAAATCTTACAAGAGATCAACAAAAGAGCTAATGATTGTTGTTTTGGTCATGAAACC
CCAAACATTCAAACGCAACAAGCCATGAGAGAAACAGATAACAAAGAAACAGATTTGTTCGTTGAGGATTTTTCTAGTTA
TAGCAATGAGAGAAAAAAGGCTTTAGGTGTTGAAGCTCAATCTTAA

Structures

Toxin

• AlphaFold DB: E8QHZ3

Antitoxin

• AlphaFold DB: E8QHZ4