Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3168707..3169370 Replicon chromosome
Accession NZ_CP116004
Organism Edwardsiella piscicida strain CC2

Toxin (Protein)


Gene name cptA Uniprot ID A0A411H3S7
Locus tag PED70_RS14650 Protein ID WP_034167931.1
Coordinates 3168707..3169123 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D0ZDY6
Locus tag PED70_RS14655 Protein ID WP_012849755.1
Coordinates 3169104..3169370 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PED70_RS14630 (PED70_14630) 3164638..3166371 - 1734 WP_012849750.1 single-stranded-DNA-specific exonuclease RecJ -
PED70_RS14635 (PED70_14635) 3166376..3167092 - 717 WP_012849751.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PED70_RS14640 (PED70_14640) 3167120..3168019 - 900 WP_012849752.1 site-specific tyrosine recombinase XerD -
PED70_RS14645 (PED70_14645) 3168170..3168682 + 513 WP_012849753.1 flavodoxin FldB -
PED70_RS14650 (PED70_14650) 3168707..3169123 - 417 WP_034167931.1 protein YgfX Toxin
PED70_RS14655 (PED70_14655) 3169104..3169370 - 267 WP_012849755.1 FAD assembly factor SdhE Antitoxin
PED70_RS14660 (PED70_14660) 3169724..3170722 + 999 WP_012849756.1 tRNA-modifying protein YgfZ -
PED70_RS14665 (PED70_14665) 3170765..3171589 - 825 WP_012849757.1 shikimate 5-dehydrogenase -
PED70_RS14670 (PED70_14670) 3171748..3172620 - 873 WP_012849758.1 nucleoside-specific channel-forming protein Tsx -
PED70_RS14675 (PED70_14675) 3173229..3173879 + 651 WP_015462279.1 hemolysin III family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16213.03 Da        Isoelectric Point: 11.6049

>T267606 WP_034167931.1 NZ_CP116004:c3169123-3168707 [Edwardsiella piscicida]
VVLWRCNVHVSWRTQVMFLLGHGALVLAILLAPWPENYSVFWLILLVAVIFECIRSQRRIARNRGELQLLAPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGAPCRRRLWLAADSMSREEWGQLRRTLLDAGDDRA

Download         Length: 417 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10318.90 Da        Isoelectric Point: 5.6951

>AT267606 WP_012849755.1 NZ_CP116004:c3169370-3169104 [Edwardsiella piscicida]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A411H3S7

Antitoxin

Source ID Structure
AlphaFold DB A0A034T2Q8

References