Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1092113..1092705 Replicon chromosome
Accession NZ_CP116004
Organism Edwardsiella piscicida strain CC2

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag PED70_RS04865 Protein ID WP_012847872.1
Coordinates 1092113..1092316 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A411GZW1
Locus tag PED70_RS04870 Protein ID WP_015461125.1
Coordinates 1092337..1092705 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PED70_RS04835 (PED70_04835) 1087838..1088299 + 462 WP_012847865.1 Lrp/AsnC family transcriptional regulator -
PED70_RS04840 (PED70_04840) 1088604..1088942 + 339 WP_012847867.1 P-II family nitrogen regulator -
PED70_RS04845 (PED70_04845) 1088964..1090244 + 1281 WP_041692495.1 ammonium transporter AmtB -
PED70_RS04850 (PED70_04850) 1090279..1091145 - 867 WP_012847869.1 acyl-CoA thioesterase II -
PED70_RS04855 (PED70_04855) 1091254..1091583 - 330 WP_225857588.1 MGMT family protein -
PED70_RS04865 (PED70_04865) 1092113..1092316 - 204 WP_012847872.1 HHA domain-containing protein Toxin
PED70_RS04870 (PED70_04870) 1092337..1092705 - 369 WP_015461125.1 Hha toxicity modulator TomB Antitoxin
PED70_RS04875 (PED70_04875) 1093074..1096227 - 3154 Protein_933 efflux RND transporter permease subunit -
PED70_RS04880 (PED70_04880) 1096271..1097455 - 1185 WP_034168424.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T267599 WP_012847872.1 NZ_CP116004:c1092316-1092113 [Edwardsiella piscicida]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14099.80 Da        Isoelectric Point: 6.1484

>AT267599 WP_015461125.1 NZ_CP116004:c1092705-1092337 [Edwardsiella piscicida]
MDEYTSYQHDIAELKYLCDSLYHQGIDVLGESHHGWVSDPTAKVNLQLNELIEHIASVAQSFKIKYPHHSDLAEILDDYL
DETYALFGAYSVSETALRHWLRTKRRVAYCLAHEKRNAALHV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB A0A411GZW1

References