Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1092316..1092908 Replicon chromosome
Accession NZ_CP116003
Organism Edwardsiella piscicida strain CC1

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag PED68_RS04865 Protein ID WP_012847872.1
Coordinates 1092316..1092519 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A411GZW1
Locus tag PED68_RS04870 Protein ID WP_015461125.1
Coordinates 1092540..1092908 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PED68_RS04835 (PED68_04835) 1088041..1088502 + 462 WP_012847865.1 Lrp/AsnC family transcriptional regulator -
PED68_RS04840 (PED68_04840) 1088807..1089145 + 339 WP_012847867.1 P-II family nitrogen regulator -
PED68_RS04845 (PED68_04845) 1089167..1090447 + 1281 WP_041692495.1 ammonium transporter AmtB -
PED68_RS04850 (PED68_04850) 1090482..1091348 - 867 WP_012847869.1 acyl-CoA thioesterase II -
PED68_RS04855 (PED68_04855) 1091457..1091786 - 330 WP_225857588.1 MGMT family protein -
PED68_RS04865 (PED68_04865) 1092316..1092519 - 204 WP_012847872.1 HHA domain-containing protein Toxin
PED68_RS04870 (PED68_04870) 1092540..1092908 - 369 WP_015461125.1 Hha toxicity modulator TomB Antitoxin
PED68_RS04875 (PED68_04875) 1093277..1096429 - 3153 WP_012847874.1 efflux RND transporter permease subunit -
PED68_RS04880 (PED68_04880) 1096473..1097657 - 1185 WP_034168424.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-64)

Antitoxin

(1-115)


Sequences


Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T267590 WP_012847872.1 NZ_CP116003:c1092519-1092316 [Edwardsiella piscicida]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp


Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14099.80 Da        Isoelectric Point: 6.1484

>AT267590 WP_015461125.1 NZ_CP116003:c1092908-1092540 [Edwardsiella piscicida]
MDEYTSYQHDIAELKYLCDSLYHQGIDVLGESHHGWVSDPTAKVNLQLNELIEHIASVAQSFKIKYPHHSDLAEILDDYL
DETYALFGAYSVSETALRHWLRTKRRVAYCLAHEKRNAALHV

Download         Length: 369 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A034SMG4


Antitoxin

Source ID Structure
AlphaFold DB A0A411GZW1

References