Detailed information of TA system TA026759

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 917436..918060
• Replicon: chromosome
• Accession: NC_017368
• Organism: Helicobacter pylori F16

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPF16_RS04460
• Protein ID: WP_000916181.1
• Coordinates: 917436..917702 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: E6NEB5
• Locus tag: HPF16_RS04465
• Protein ID: WP_001133872.1
• Coordinates: 917683..918060 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPF16_RS04440	914078..914845	-	768	WP_000242357.1	ABC transporter ATP-binding protein	-
HPF16_RS04445	914845..915825	-	981	WP_000921481.1	iron ABC transporter permease	-
HPF16_RS04450	915818..916666	-	849	WP_000504087.1	SDR family oxidoreductase	-
HPF16_RS04455	916806..917330	+	525	WP_001120212.1	acyl-CoA thioesterase	-
HPF16_RS04460	917436..917702	-	267	WP_000916181.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HPF16_RS04465	917683..918060	-	378	WP_001133872.1	hypothetical protein	Antitoxin
HPF16_RS04470	918675..920906	-	2232	WP_000716220.1	Hop family adhesin BabA	-
HPF16_RS04485	921365..921886	+	522	WP_000427286.1	hypothetical protein	-
HPF16_RS04490	921837..922949	-	1113	WP_000115684.1	hydrogenase formation protein HypD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10305.17 Da
• Isoelectric Point: 10.0672

>T26759 WP_000916181.1 NC_017368:c917702-917436 [Helicobacter pylori F16]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFQDHALKGKWKPFREYHIKADILLVYLVKGDELILVR
LGSHSELF

Nucleotide

• Length: 267 bp

>T26759 NC_017368:c917702-917436 [Helicobacter pylori F16]
GTGTTGAAACTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATAAGGTCATTCTGTCTTTGAGAAAAAAAGAACCGCTAGACCCACAATTTCAAGATCATGCTTTAAAGGGAAAGTGGA
AACCTTTTAGGGAATACCACATCAAAGCTGATATTTTACTTGTTTATTTGGTGAAAGGTGATGAGCTTATTTTAGTAAGA
CTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14866.74 Da
• Isoelectric Point: 6.9600

>AT26759 WP_001133872.1 NC_017368:c918060-917683 [Helicobacter pylori F16]
MPNSPTKKDYTRYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELDKRDQNFKDKIDALNELLQKISQAFDDKRDCCF
RHEIPNLETQQAMRDALNKETDLIVEDFSNYSDERKRALGVETQS

Nucleotide

• Length: 378 bp

>AT26759 NC_017368:c918060-917683 [Helicobacter pylori F16]
ATGCCTAATTCTCCCACCAAAAAAGACTACACACGATACAGCGAAAAACAGCTTTTTAACTTAATCAATCAATTAGAGCA
AAAGATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGACAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTT
AGGCATGAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGCTAAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAATTATAGCGATGAAAGAAAAAGGGCGTTAGGTGTTGAAACTCAATCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1Q2PWQ0