267589

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 104262..105399 Replicon plasmid pESC2
Accession NZ_CP115994
Organism Enterococcus faecalis strain ESC1

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag PE069_RS14960 Protein ID WP_002333003.1
Coordinates 104262..105125 (-) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID B3CKC7
Locus tag PE069_RS14965 Protein ID WP_002333002.1
Coordinates 105127..105399 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PE069_RS14935 (99555) 99555..100061 + 507 WP_271232482.1 IS30 family transposase -
PE069_RS14940 (100133) 100133..101746 - 1614 WP_002333004.1 hypothetical protein -
PE069_RS14945 (101770) 101770..102651 - 882 WP_002326774.1 ABC transporter ATP-binding protein -
PE069_RS14950 (102962) 102962..103558 + 597 WP_085442989.1 TetR/AcrR family transcriptional regulator -
PE069_RS14955 (103727) 103727..104131 - 405 Protein_115 DnaJ domain-containing protein -
PE069_RS14960 (104262) 104262..105125 - 864 WP_002333003.1 zeta toxin family protein Toxin
PE069_RS14965 (105127) 105127..105399 - 273 WP_002333002.1 antitoxin Antitoxin
PE069_RS14970 (105417) 105417..105632 - 216 WP_001835296.1 peptide-binding protein -
PE069_RS14975 (105724) 105724..106620 - 897 WP_104681373.1 ParA family protein -
PE069_RS14980 (106723) 106723..108558 - 1836 WP_232035937.1 type IA DNA topoisomerase -
PE069_RS14985 (108788) 108788..109006 + 219 WP_271232473.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid erm(A) / optrA / fexA / cat / tet(L) / tet(M) / dfrG / aph(3')-III / erm(B) prgB/asc10 / asa1 1..141731 141731


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32365.76 Da        Isoelectric Point: 6.3643

>T267589 WP_002333003.1 NZ_CP115994:c105125-104262 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELVQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVVVIDNDTFKQQHPNFDELV
KLYEKDVVKHATPYSNRMTEALISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKTYAMAVPKIESYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGI

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.29 Da        Isoelectric Point: 7.1987

>AT267589 WP_002333002.1 NZ_CP115994:c105399-105127 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELKAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2Z6BWJ3

References