267574

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 1885155..1885726 Replicon chromosome
Accession NZ_CP115992
Organism Enterococcus faecalis strain ESC1

Toxin (Protein)


Gene name mazF Uniprot ID R3GRA7
Locus tag PE069_RS09020 Protein ID WP_002360937.1
Coordinates 1885155..1885496 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S4CGQ1
Locus tag PE069_RS09025 Protein ID WP_002367500.1
Coordinates 1885496..1885726 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PE069_RS09015 (1881019) 1881019..1884633 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
PE069_RS09020 (1885155) 1885155..1885496 - 342 WP_002360937.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PE069_RS09025 (1885496) 1885496..1885726 - 231 WP_002367500.1 hypothetical protein Antitoxin
PE069_RS09030 (1886049) 1886049..1886264 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
PE069_RS09035 (1886403) 1886403..1887395 + 993 WP_192177101.1 biotin--[acetyl-CoA-carboxylase] ligase -
PE069_RS09040 (1887485) 1887485..1888084 - 600 WP_225560887.1 RloB family protein -
PE069_RS09045 (1888093) 1888093..1889388 - 1296 WP_192177102.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13165.41 Da        Isoelectric Point: 9.3988

>T267574 WP_002360937.1 NZ_CP115992:c1885496-1885155 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8704.69 Da        Isoelectric Point: 4.3313

>AT267574 WP_002367500.1 NZ_CP115992:c1885726-1885496 [Enterococcus faecalis]
MLTTKSRRQGNSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2A7G9

Antitoxin

Source ID Structure
AlphaFold DB S4CGQ1

References