Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 487635..488259 Replicon chromosome
Accession NC_017366
Organism Helicobacter pylori F32

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HPF32_RS02380 Protein ID WP_000916167.1
Coordinates 487993..488259 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID E6NNW2
Locus tag HPF32_RS02375 Protein ID WP_001133862.1
Coordinates 487635..488012 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPF32_RS02350 482754..483866 + 1113 WP_000115664.1 hydrogenase formation protein HypD -
HPF32_RS02355 483817..484338 - 522 WP_000427288.1 hypothetical protein -
HPF32_RS02370 484869..487085 + 2217 WP_000716210.1 Hop family adhesin BabA -
HPF32_RS02375 487635..488012 + 378 WP_001133862.1 hypothetical protein Antitoxin
HPF32_RS02380 487993..488259 + 267 WP_000916167.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HPF32_RS02385 488343..488867 - 525 WP_001120215.1 acyl-CoA thioesterase -
HPF32_RS02390 489008..489850 + 843 WP_000504082.1 SDR family oxidoreductase -
HPF32_RS02395 489843..490823 + 981 WP_000921482.1 iron ABC transporter permease -
HPF32_RS02400 490823..491590 + 768 WP_000242368.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10274.09 Da        Isoelectric Point: 9.0318

>T26757 WP_000916167.1 NC_017366:487993-488259 [Helicobacter pylori F32]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVILTLRKKEPLDPQFKDHALKGNWKPFRECHIKADILLVYLVRGDELILVR
LGSHSELF

Download         Length: 267 bp

>T26757 NC_017366:487993-488259 [Helicobacter pylori F32]
GTGTTGAAACTCAACCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATGAAGTCATTCTAACCTTAAGAAAGAAAGAACCACTAGACCCACAATTTAAAGATCATGCTTTAAAAGGCAATTGGA
AACCTTTTAGGGAATGCCACATCAAAGCTGATATTTTGCTTGTGTATTTAGTGAGAGGTGATGAGCTTATTTTAGTAAGA
CTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14720.68 Da        Isoelectric Point: 7.7778

>AT26757 WP_001133862.1 NC_017366:487635-488012 [Helicobacter pylori F32]
MPNSPTKKDYTQYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GRKIPNLETQQAMRDALNKETDLIVEDFSSYSDERKRALGVETQP

Download         Length: 378 bp

>AT26757 NC_017366:487635-488012 [Helicobacter pylori F32]
ATGCCTAACTCTCCCACCAAAAAAGACTACACGCAATACAGCGAAAAACAGCTTTTTAACTTAATCAATCAATTAGAGCA
AAAAATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCGCAAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCACTTAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAGTTATAGCGATGAAAGAAAAAGGGCGTTAGGTGTTGAAACTCAACCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB E6NNW2

References