Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_26(antitoxin)
Location 1536539..1537237 Replicon chromosome
Accession NZ_CP115992
Organism Enterococcus faecalis strain ESC1

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag PE069_RS07380 Protein ID WP_010827745.1
Coordinates 1536893..1537237 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag PE069_RS07375 Protein ID WP_023895324.1
Coordinates 1536539..1536874 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PE069_RS07325 (1531666) 1531666..1532421 - 756 WP_271232260.1 DnaD domain protein -
PE069_RS07330 (1532436) 1532436..1533251 - 816 WP_161972134.1 PD-(D/E)XK nuclease-like domain-containing protein -
PE069_RS07335 (1533214) 1533214..1534185 - 972 WP_104878921.1 RecT family recombinase -
PE069_RS07340 (1534235) 1534235..1534555 + 321 WP_010707143.1 hypothetical protein -
PE069_RS07345 (1534574) 1534574..1534879 - 306 WP_002395805.1 hypothetical protein -
PE069_RS07350 (1534982) 1534982..1535206 - 225 WP_002367281.1 hypothetical protein -
PE069_RS07355 (1535203) 1535203..1535502 - 300 WP_010706856.1 hypothetical protein -
PE069_RS07360 (1535569) 1535569..1535748 - 180 WP_010829956.1 hypothetical protein -
PE069_RS07365 (1535783) 1535783..1536052 - 270 WP_002365131.1 hypothetical protein -
PE069_RS07370 (1536065) 1536065..1536247 - 183 WP_002358110.1 hypothetical protein -
PE069_RS07375 (1536539) 1536539..1536874 + 336 WP_023895324.1 helix-turn-helix transcriptional regulator Antitoxin
PE069_RS07380 (1536893) 1536893..1537237 + 345 WP_010827745.1 ImmA/IrrE family metallo-endopeptidase Toxin
PE069_RS07385 (1537295) 1537295..1538023 + 729 WP_002385631.1 potassium channel family protein -
PE069_RS07390 (1538178) 1538178..1539359 + 1182 WP_271232261.1 site-specific integrase -
PE069_RS07395 (1539462) 1539462..1539611 - 150 WP_002356321.1 50S ribosomal protein L33 -
PE069_RS07400 (1539737) 1539737..1541872 - 2136 WP_002359399.1 penicillin-binding protein 2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1496526..1539359 42833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(21-86)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-60)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13580.58 Da        Isoelectric Point: 5.6177

>T267564 WP_010827745.1 NZ_CP115992:1536893-1537237 [Enterococcus faecalis]
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKDHVDIMALYKIPVFRSKMEAEAEQ
YMFRSLIEKYEGQYNYSNVIAHYNLKMGQEVYLK

Download         Length: 345 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12843.45 Da        Isoelectric Point: 4.8252

>AT267564 WP_023895324.1 NZ_CP115992:1536539-1536874 [Enterococcus faecalis]
MTVFDRIKLLAKERGKSLNRIEEELGLPKNVLYRMKTSDNPTKDRLETLANYFDVSVDYLLGRTDNTKATDEKKSDDLDD
VLDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References