Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-YefM
Location 2093671..2094386 Replicon chromosome
Accession NZ_CP115971
Organism Actinobacillus pleuropneumoniae strain HBS1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PE794_RS10005 Protein ID WP_005599445.1
Coordinates 2093671..2094036 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B0BT01
Locus tag PE794_RS10010 Protein ID WP_005599447.1
Coordinates 2094099..2094386 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PE794_RS09990 (PE794_09990) 2089256..2090962 - 1707 WP_005599433.1 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase -
PE794_RS09995 (PE794_09995) 2091058..2091339 - 282 WP_005599441.1 DNA-directed RNA polymerase subunit omega -
PE794_RS10000 (PE794_10000) 2091466..2093547 - 2082 WP_005599444.1 ATP-dependent DNA helicase RecG -
PE794_RS10005 (PE794_10005) 2093671..2094036 - 366 WP_005599445.1 type II toxin-antitoxin system VapC family toxin Toxin
PE794_RS10010 (PE794_10010) 2094099..2094386 - 288 WP_005599447.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PE794_RS10015 (PE794_10015) 2094592..2096307 + 1716 WP_005599448.1 proline--tRNA ligase -
PE794_RS10020 (PE794_10020) 2096373..2096561 - 189 WP_005602684.1 hypothetical protein -
PE794_RS10025 (PE794_10025) 2096564..2097145 - 582 WP_005599450.1 sigma-70 family RNA polymerase sigma factor -
PE794_RS10030 (PE794_10030) 2097234..2098190 + 957 WP_005619040.1 protein-methionine-sulfoxide reductase catalytic subunit MsrP -
PE794_RS10035 (PE794_10035) 2098190..2098783 + 594 WP_005599453.1 protein-methionine-sulfoxide reductase heme-binding subunit MsrQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13974.06 Da        Isoelectric Point: 9.0549

>T267563 WP_005599445.1 NZ_CP115971:c2094036-2093671 [Actinobacillus pleuropneumoniae]
MDTNVRQWLATIKPSQTNISCITLSEIKTGILLKARKDPIQAERLNHWFTHNVLSVYQAKSFSINNEIALLASEYHIPNK
MDLNDAYIAATAKYHNLVLVTRNLKDFNRCDIRLFNPFEPN

Download         Length: 366 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11040.29 Da        Isoelectric Point: 4.5578

>AT267563 WP_005599447.1 NZ_CP115971:c2094386-2094099 [Actinobacillus pleuropneumoniae]
MPITITSREFNQHASKVLKMAEKEPVFITKWGKIVSVVSNYVDYKQHTTVEPSFEELFASSTDESVSDEFWQDFEQTLTK
IRKSNKSEQIDFGDE

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A3N3C5

References