Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2010540..2011168 Replicon chromosome
Accession NZ_CP115971
Organism Actinobacillus pleuropneumoniae strain HBS1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PE794_RS09500 Protein ID WP_005599242.1
Coordinates 2010770..2011168 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A828PGB0
Locus tag PE794_RS09495 Protein ID WP_005599241.1
Coordinates 2010540..2010770 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PE794_RS09485 (PE794_09485) 2008513..2010099 + 1587 WP_005599240.1 DUF262 domain-containing protein -
PE794_RS09490 (PE794_09490) 2010292..2010465 - 174 Protein_1826 addiction module antidote protein, HigA family -
PE794_RS09495 (PE794_09495) 2010540..2010770 + 231 WP_005599241.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
PE794_RS09500 (PE794_09500) 2010770..2011168 + 399 WP_005599242.1 tRNA(fMet)-specific endonuclease VapC Toxin
PE794_RS09505 (PE794_09505) 2011303..2011719 - 417 WP_005599244.1 DUF417 family protein -
PE794_RS09510 (PE794_09510) 2011956..2013146 - 1191 WP_005599245.1 pentapeptide repeat-containing protein -
PE794_RS09515 (PE794_09515) 2013199..2014521 - 1323 WP_005620148.1 HslU--HslV peptidase ATPase subunit -
PE794_RS09520 (PE794_09520) 2014667..2015188 - 522 WP_005599247.1 ATP-dependent protease subunit HslV -
PE794_RS09525 (PE794_09525) 2015266..2015977 - 712 Protein_1833 DNA/RNA nuclease SfsA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1995161..2013146 17985


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(6-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15028.31 Da        Isoelectric Point: 7.4716

>T267562 WP_005599242.1 NZ_CP115971:2010770-2011168 [Actinobacillus pleuropneumoniae]
MLTYMLDTNIAIYVIKRRPLEVLDKFNLNSTRLCVSSITAAELYYGAEKSQFPEQNMAVIEDFLSRLTILDYTHKAATHF
GNIKAHLSKHGKIIGENDIHIAAHARSEGLVLVTNNLREFERVEGLRLANWV

Download         Length: 399 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8561.71 Da        Isoelectric Point: 4.7063

>AT267562 WP_005599241.1 NZ_CP115971:2010540-2010770 [Actinobacillus pleuropneumoniae]
MEASVFMTNRSQAVRLPAEVRFASDVKKLSVRVVGNERILAPINQSWDSFFLGSATVSDDFMTEREISIQPEREGL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A828PGB0

References