Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1797112..1797843 Replicon chromosome
Accession NZ_CP115971
Organism Actinobacillus pleuropneumoniae strain HBS1

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag PE794_RS08430 Protein ID WP_005598840.1
Coordinates 1797112..1797579 (-) Length 156 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID B0BRD3
Locus tag PE794_RS08435 Protein ID WP_005619269.1
Coordinates 1797583..1797843 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PE794_RS08405 (PE794_08405) 1792471..1792842 - 372 WP_005598830.1 CrcB family protein -
PE794_RS08410 (PE794_08410) 1792845..1793909 - 1065 WP_043991897.1 MFS transporter -
PE794_RS08415 (PE794_08415) 1794004..1795113 + 1110 WP_005598834.1 anhydro-N-acetylmuramic acid kinase -
PE794_RS08420 (PE794_08420) 1795167..1796081 + 915 WP_005598836.1 N-acetylmuramic acid 6-phosphate etherase -
PE794_RS08425 (PE794_08425) 1796148..1797029 - 882 WP_005598838.1 50S ribosomal protein L11 methyltransferase -
PE794_RS08430 (PE794_08430) 1797112..1797579 - 468 WP_005598840.1 GNAT family N-acetyltransferase Toxin
PE794_RS08435 (PE794_08435) 1797583..1797843 - 261 WP_005619269.1 DUF1778 domain-containing protein Antitoxin
PE794_RS08440 (PE794_08440) 1797964..1799424 - 1461 WP_005598844.1 metalloprotease TldD -
PE794_RS08445 (PE794_08445) 1799554..1800813 + 1260 WP_005598846.1 tRNA lysidine(34) synthetase TilS -
PE794_RS08450 (PE794_08450) 1800840..1801130 - 291 WP_005598848.1 DUF5389 family protein -
PE794_RS08455 (PE794_08455) 1801132..1802025 - 894 WP_005598850.1 site-specific tyrosine recombinase XerD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(22-142)

Antitoxin

Vibrio phage ICP1, Orf50

(6-80)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 17206.22 Da        Isoelectric Point: 8.9312

>T267561 WP_005598840.1 NZ_CP115971:c1797579-1797112 [Actinobacillus pleuropneumoniae]
MHAPELLSEQHIVRYFQCGEVVLDQWLQRTALKNQQNNASKTFVVCDENKQVMGFYCLSAGSVSHQFVAGALRRNMPDPI
PVIILGRLAVDCSAQGKQLGVSMLKDAVLKSKTVANQIGIKALLVHALNPQAKQFYLKYGFSCSPIDEMVLMLKL

Download         Length: 468 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9796.14 Da        Isoelectric Point: 4.4883

>AT267561 WP_005619269.1 NZ_CP115971:c1797843-1797583 [Actinobacillus pleuropneumoniae]
MRTAPINLRAMPDQRDLIDYAASILGKTRSDFMLETACQAAQNVILDRTVFQLNEQAFEQFNRLLEQPTADNPGLDKLLN
TKAVWE

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A3N2I7

References