Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxTA/Tad-couple_hipB
Location 1588779..1589424 Replicon chromosome
Accession NZ_CP115971
Organism Actinobacillus pleuropneumoniae strain HBS1

Toxin (Protein)


Gene name toxT Uniprot ID B0BQU7
Locus tag PE794_RS07415 Protein ID WP_005619674.1
Coordinates 1589053..1589424 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag PE794_RS07410 Protein ID WP_005598477.1
Coordinates 1588779..1589072 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PE794_RS07380 (PE794_07380) 1584120..1584803 - 684 WP_005598468.1 arginine ABC transporter permease ArtM -
PE794_RS07385 (PE794_07385) 1584803..1585474 - 672 WP_005598470.1 arginine ABC transporter permease ArtQ -
PE794_RS07390 (PE794_07390) 1585480..1586199 - 720 WP_043991873.1 transporter substrate-binding domain-containing protein -
PE794_RS07395 (PE794_07395) 1586219..1586953 - 735 WP_005598473.1 arginine ABC transporter ATP-binding protein ArtP -
PE794_RS07400 (PE794_07400) 1587178..1587675 - 498 WP_005598474.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
PE794_RS07405 (PE794_07405) 1587748..1588701 + 954 WP_043991874.1 calcium/sodium antiporter -
PE794_RS07410 (PE794_07410) 1588779..1589072 - 294 WP_005598477.1 helix-turn-helix domain-containing protein Antitoxin
PE794_RS07415 (PE794_07415) 1589053..1589424 - 372 WP_005619674.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PE794_RS07420 (PE794_07420) 1589618..1591369 + 1752 WP_005598482.1 protein-disulfide reductase DsbD -
PE794_RS07425 (PE794_07425) 1591427..1591996 + 570 WP_005598484.1 elongation factor P hydroxylase -
PE794_RS07430 (PE794_07430) 1592040..1592894 - 855 WP_005598486.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(32-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-85)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 15066.57 Da        Isoelectric Point: 10.4054

>T267560 WP_005619674.1 NZ_CP115971:c1589424-1589053 [Actinobacillus pleuropneumoniae]
MYEIVFYRDKRGREPVKEFLLRLLKERQEGSRERLHKISHHLSILHLHGTRAGENYIKHLEDRIWQLRPVGDCLLFASII
RGKFVLLHYFAKQNYRIPKREIERAKVRLADLQERIKDEPYWF

Download         Length: 372 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10935.81 Da        Isoelectric Point: 10.3120

>AT267560 WP_005598477.1 NZ_CP115971:c1589072-1588779 [Actinobacillus pleuropneumoniae]
MSPIGSSWTSFEQEIFDESEIAETQFRIRLILEIIETRQQLGISQRKLEKLSGVKQSMIARVEKGSVNPSLATVLKLLVP
LGKTLQIVPLDKNKTVR

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A3N206

Antitoxin

Source ID Structure

References