Detailed information of TA system TA026756

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 1469147..1470353
• Replicon: chromosome
• Accession: NC_017365
• Organism: Helicobacter pylori F30

Toxin (Protein)

• Gene name: panT
• Uniprot ID: E6NGU9
• Locus tag: HPF30_RS07165
• Protein ID: WP_000448211.1
• Coordinates: 1469147..1469926 (-)
• Length: 260 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: X2IFS3
• Locus tag: HPF30_RS07170
• Protein ID: WP_000245673.1
• Coordinates: 1469916..1470353 (-)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPF30_RS07155	1466515..1467675	+	1161	WP_001051159.1	L-seryl-tRNA(Sec) selenium transferase	-
HPF30_RS07160	1467763..1468950	+	1188	WP_000411589.1	transcription termination/antitermination protein NusA	-
HPF30_RS07165	1469147..1469926	-	780	WP_000448211.1	hypothetical protein	Toxin
HPF30_RS07170	1469916..1470353	-	438	WP_000245673.1	SocA family protein	Antitoxin
HPF30_RS07175	1470579..1472205	-	1627	Protein_1372	RNA-directed DNA polymerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 260 a.a.
• Molecular weight: 30370.57 Da
• Isoelectric Point: 8.8130

>T26756 WP_000448211.1 NC_017365:c1469926-1469147 [Helicobacter pylori F30]
METKEEDKDKKLEKIIVLLCEEGDLSSQKDQIIKDLKEIYEGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDISIRLDNLNKNYKKLSEELNKQQTQYITILGIFASIILTFVG
GLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILHLLFSFLSKISLSSKISLSKEERDKQENFFKKPIFWFNLMVTILF
MIGFVGELHIIQRLASKYF

Nucleotide

• Length: 780 bp

>T26756 NC_017365:c1469926-1469147 [Helicobacter pylori F30]
ATGGAAACTAAAGAAGAGGATAAAGATAAAAAGCTAGAAAAAATTATTGTATTGTTGTGCGAAGAGGGGGATTTGTCTAG
CCAAAAAGATCAAATCATCAAAGATCTCAAAGAAATCTATGAAGGAGAATACAAGCATAAATACTCAAAAATCACAACTA
TTATTTTAAATTCCACAAGAGATAAAGAGCAAGCCTTTATGATGCTCACACAAAATATAAAGACACTCAAAGAGATTCAA
GATAATAAGGAAGTTGAAAGCATTAAGCCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATATTTCTATAAGGTTAGATAATCTAAATAAAAACTATAAAAAATTAA
GCGAAGAATTGAATAAGCAACAAACACAATACATAACAATTCTAGGTATTTTTGCCTCTATTATTTTAACATTTGTTGGG
GGATTGGCGTTTTCTACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTATCGTTTGGTTTTTGTTATGGCTTTTAT
AGCTTTATTTTTTGGGAATATTTTGCATCTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCATCAAAAATATCCTTAT
CAAAAGAGGAAAGAGATAAACAAGAAAATTTTTTCAAAAAACCTATTTTTTGGTTTAATCTGATGGTTACAATCCTATTT
ATGATTGGTTTTGTGGGAGAATTGCATATAATACAAAGATTAGCTTCTAAATATTTTTAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17309.47 Da
• Isoelectric Point: 6.7306

>AT26756 WP_000245673.1 NC_017365:c1470353-1469916 [Helicobacter pylori F30]
MVNALELAKYILKRSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLRKDELETINYSIEKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEVISKDLIKREAKQANGN

Nucleotide

• Length: 438 bp

>AT26756 NC_017365:c1470353-1469916 [Helicobacter pylori F30]
ATGGTCAATGCTTTGGAACTAGCAAAATATATTCTTAAGCGTTCAAACAAAGAATTGAGCAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATCAAAAAGTTTGACAAACATCTAGTTTCTGATGATTTTGAAGCTTGGAAATATG
GGCCTGTTGCAAGGGAAGTGTATTATGAATATCGCAATTATGGTGCCAATTCCATTGACAAACCCAAAGAAGAAACGCTC
TCACAAAATCTTAGAAAAGATGAATTGGAAACCATCAACTACTCTATAGAAAAATGCAACGAGAAATCCTATTGGGATTT
AGTGAAAGAGAGTCATAAGGAAGATGGTGCTTGGCATAAAAGCTTCAAAGAAGATAGAAAAGAAGTCATTAGCAAAGATT
TGATCAAACGAGAAGCAAAACAAGCAAATGGAAACTAA

Structures

Toxin

• AlphaFold DB: E6NGU9

Antitoxin

• AlphaFold DB: X2IFS3