Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 1502684..1503192 Replicon chromosome
Accession NZ_CP115971
Organism Actinobacillus pleuropneumoniae strain HBS1

Toxin (Protein)


Gene name relE Uniprot ID B0BQK9
Locus tag PE794_RS06955 Protein ID WP_005605064.1
Coordinates 1502932..1503192 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B0BQK8
Locus tag PE794_RS06950 Protein ID WP_005598318.1
Coordinates 1502684..1502935 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PE794_RS06910 (PE794_06910) 1498221..1498769 - 549 WP_005598298.1 type IV pilus biogenesis/stability protein PilW -
PE794_RS06915 (PE794_06915) 1498823..1500004 - 1182 WP_005598300.1 bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN -
PE794_RS06940 (PE794_06940) 1500908..1502347 + 1440 WP_005598316.1 glutamate--tRNA ligase -
PE794_RS06950 (PE794_06950) 1502684..1502935 + 252 WP_005598318.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
PE794_RS06955 (PE794_06955) 1502932..1503192 + 261 WP_005605064.1 Txe/YoeB family addiction module toxin Toxin
PE794_RS06960 (PE794_06960) 1503351..1503518 - 168 WP_005598320.1 Trm112 family protein -
PE794_RS06965 (PE794_06965) 1503520..1504500 - 981 WP_005598322.1 tetraacyldisaccharide 4'-kinase -
PE794_RS06970 (PE794_06970) 1504594..1505853 - 1260 WP_005598324.1 ATP-dependent protease ATP-binding subunit ClpX -
PE794_RS06975 (PE794_06975) 1505853..1506443 - 591 WP_005598326.1 ATP-dependent Clp endopeptidase proteolytic subunit ClpP -
PE794_RS06980 (PE794_06980) 1506565..1506957 + 393 WP_005620423.1 SufE family protein -
PE794_RS06995 (PE794_06995) 1507316..1508089 - 774 WP_005598329.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10423.99 Da        Isoelectric Point: 8.0109

>T267559 WP_005605064.1 NZ_CP115971:1502932-1503192 [Actinobacillus pleuropneumoniae]
MKLTFSSNAWEDYLYWQKTDKIILKRINSLIKDIQRQPFEGIGKLEPLKFNLSGFWSRRINEEHRLIYSVEDEAILIVAC
RYHYDQ

Download         Length: 261 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9362.66 Da        Isoelectric Point: 4.5659

>AT267559 WP_005598318.1 NZ_CP115971:1502684-1502935 [Actinobacillus pleuropneumoniae]
MQAITYTEARQNLAGTMSKVAEDFEPILITRSKGGNCVLMSYEQYCSLEETAYLMRSPTNAKRLLDSVAELRQGQGIERE
LIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B0BQK9

Antitoxin

Source ID Structure
AlphaFold DB B0BQK8

References