Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 3396188..3396821 Replicon chromosome
Accession NZ_CP115957
Organism Ralstonia pseudosolanacearum strain PSS4

Toxin (Protein)


Gene name vapC Uniprot ID Q8XUX8
Locus tag PG908_RS16200 Protein ID WP_011002948.1
Coordinates 3396188..3396601 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q8XUX7
Locus tag PG908_RS16205 Protein ID WP_011002949.1
Coordinates 3396588..3396821 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG908_RS16180 3391564..3393306 + 1743 WP_011002944.1 ABC transporter substrate-binding protein -
PG908_RS16185 3393468..3394964 + 1497 WP_011002945.1 glycerol kinase GlpK -
PG908_RS16190 3395025..3395396 - 372 WP_011002946.1 hypothetical protein -
PG908_RS16195 3395587..3396213 + 627 WP_011002947.1 DUF1415 domain-containing protein -
PG908_RS16200 3396188..3396601 - 414 WP_011002948.1 PIN domain-containing protein Toxin
PG908_RS16205 3396588..3396821 - 234 WP_011002949.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
PG908_RS16210 3396878..3398485 - 1608 WP_043876668.1 glucan biosynthesis protein -
PG908_RS16215 3398698..3399930 + 1233 WP_011002951.1 AGE family epimerase/isomerase -
PG908_RS16220 3399938..3401233 + 1296 WP_011002952.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-116)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15101.45 Da        Isoelectric Point: 5.5348

>T267553 WP_011002948.1 NZ_CP115957:c3396601-3396188 [Ralstonia pseudosolanacearum]
MPATEAFFDSNVVLYLLSADTAKADAAETLLMTGGVVTVQVLNETTHVMRRKLAMPWHAIETVQEAVRAQCRVEPLTLET
HDLGRRIAERYGLSVYDALIVAAALLAGCNVLYSEDMQHGLVIEQHLRIVNPFPARA

Download         Length: 414 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8790.98 Da        Isoelectric Point: 8.7287

>AT267553 WP_011002949.1 NZ_CP115957:c3396821-3396588 [Ralstonia pseudosolanacearum]
MQVSKWGNSLAIRLPAAVVEALQLHEGDDVEVVIAGERSFGVRRKRAARELFDRIHQYRGKLPADFIFERDQANARD

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8XUX8

Antitoxin

Source ID Structure
AlphaFold DB A0A223GR76

References