Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1884257..1884846 Replicon chromosome
Accession NZ_CP115957
Organism Ralstonia pseudosolanacearum strain PSS4

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PG908_RS08745 Protein ID WP_043876605.1
Coordinates 1884257..1884511 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q8XYR1
Locus tag PG908_RS08750 Protein ID WP_011001638.1
Coordinates 1884508..1884846 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG908_RS08725 1879497..1879988 - 492 WP_011001641.1 glycoside hydrolase family protein -
PG908_RS08730 1880057..1880713 - 657 WP_011001640.1 hypothetical protein -
PG908_RS08735 1880739..1881050 - 312 WP_043876606.1 hypothetical protein -
PG908_RS08740 1881050..1884205 - 3156 WP_011001639.1 host specificity protein J -
PG908_RS08745 1884257..1884511 + 255 WP_043876605.1 type II toxin-antitoxin system HicA family toxin Toxin
PG908_RS08750 1884508..1884846 + 339 WP_011001638.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PG908_RS08755 1884916..1885518 - 603 WP_011001637.1 tail assembly protein -
PG908_RS08760 1885522..1886232 - 711 WP_011001636.1 C40 family peptidase -
PG908_RS08765 1886234..1886935 - 702 WP_011001635.1 phage minor tail protein L -
PG908_RS08770 1886932..1887528 - 597 WP_011001634.1 tail fiber assembly protein -
PG908_RS08775 1887534..1888211 - 678 WP_011001633.1 phage tail protein -
PG908_RS08780 1888208..1888546 - 339 WP_011001632.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1865000..1915132 50132


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9488.05 Da        Isoelectric Point: 10.3121

>T267552 WP_043876605.1 NZ_CP115957:1884257-1884511 [Ralstonia pseudosolanacearum]
MKAKHQKTLELIFSRPTPAGVKWTDAVALMRELGAELEEREGSRVAVFLFGQVKVMHRPHPSPDMDKGAVASMRKWFEEN
GVKP

Download         Length: 255 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12007.63 Da        Isoelectric Point: 5.1236

>AT267552 WP_011001638.1 NZ_CP115957:1884508-1884846 [Ralstonia pseudosolanacearum]
MINVMNIGGHKAVIAYDPDIEMFRGEFVGLNGGADFYAADVPGLHREGELSLHVFLEECARRGVEPQKHFSGKFMLRVEG
KVHEAATIAAAAQGVSLNQWAAGVLEQAAEAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q8XYR1

References