Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1608159..1609745 Replicon chromosome
Accession NZ_CP115957
Organism Ralstonia pseudosolanacearum strain PSS4

Toxin (Protein)


Gene name hipA Uniprot ID Q8XZF5
Locus tag PG908_RS07705 Protein ID WP_011001395.1
Coordinates 1608159..1609496 (-) Length 446 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A223GLT8
Locus tag PG908_RS07710 Protein ID WP_028853251.1
Coordinates 1609500..1609745 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG908_RS07680 1603804..1604544 + 741 WP_011001390.1 protocatechuate 3,4-dioxygenase subunit beta -
PG908_RS07685 1604541..1605239 + 699 WP_019718855.1 protocatechuate 3,4-dioxygenase subunit alpha -
PG908_RS07690 1605387..1605983 + 597 WP_011001392.1 RNA 2',3'-cyclic phosphodiesterase -
PG908_RS07695 1606006..1606734 - 729 WP_011001393.1 DsbA family protein -
PG908_RS07700 1606960..1608162 - 1203 WP_011001394.1 MFS transporter -
PG908_RS07705 1608159..1609496 - 1338 WP_011001395.1 type II toxin-antitoxin system HipA family toxin Toxin
PG908_RS07710 1609500..1609745 - 246 WP_028853251.1 helix-turn-helix transcriptional regulator Antitoxin
PG908_RS07715 1609849..1610688 - 840 WP_011001397.1 oxaloacetate decarboxylase -
PG908_RS07720 1611006..1611644 + 639 WP_011001398.1 7-carboxy-7-deazaguanine synthase -
PG908_RS07725 1611712..1612188 + 477 WP_011001399.1 6-carboxytetrahydropterin synthase QueD -
PG908_RS07730 1612208..1612759 + 552 WP_011001400.1 tRNA adenosine(34) deaminase TadA -
PG908_RS07735 1612756..1613682 + 927 WP_011001401.1 muramoyltetrapeptide carboxypeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1595808..1612188 16380


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-63)


Sequences

Toxin        


Download         Length: 446 a.a.        Molecular weight: 48742.83 Da        Isoelectric Point: 6.7232

>T267551 WP_011001395.1 NZ_CP115957:c1609496-1608159 [Ralstonia pseudosolanacearum]
MAHPELHLWMNGEHVGIWTASRAGVPILRYDDAWLRSPNMRPLSLSLPIPAGVPELRGQVVDDYFDNLLPEAQPIRERVR
RRFGLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRIDSEALTDSQVDTLLRNLTAMPALGEDAGDPDAFRISIAGA
QEKTALLRIGDAWHRPLGATPTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLAAWGLEVARTEIARFGASKVLAVERF
DRRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMRACLDLLSASEHAIDDKRRFVLAQLAFWLLAATDGHAKNFS
LAIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAMALRGKNAHARLADIHVRHWQALAAQSGVPDAFAGMQALVE
RVPAGLERVEAILPPDFSGRVWSSVRTGVLAQAERFLNELASVTP

Download         Length: 1338 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8482.80 Da        Isoelectric Point: 10.4693

>AT267551 WP_028853251.1 NZ_CP115957:c1609745-1609500 [Ralstonia pseudosolanacearum]
MESLLSSAPQLSAHLKSLRKARGLTQAQLGALLGVSQNRIADIEKDPGAVGFEQLLRILHALGAQLTLRTSAPAAAAPAD
W

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8XZF5

Antitoxin

Source ID Structure
AlphaFold DB A0A223GLT8

References