Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 476556..477180 Replicon chromosome
Accession NC_017365
Organism Helicobacter pylori F30

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HPF30_RS02380 Protein ID WP_000916178.1
Coordinates 476914..477180 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID E6NEB5
Locus tag HPF30_RS02375 Protein ID WP_001133872.1
Coordinates 476556..476933 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPF30_RS02345 471615..472727 + 1113 WP_000115685.1 hydrogenase formation protein HypD -
HPF30_RS02350 472678..473199 - 522 WP_000427272.1 hypothetical protein -
HPF30_RS02370 473720..475945 + 2226 WP_000716304.1 Hop family adhesin BabA -
HPF30_RS02375 476556..476933 + 378 WP_001133872.1 hypothetical protein Antitoxin
HPF30_RS02380 476914..477180 + 267 WP_000916178.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HPF30_RS02385 477286..477810 - 525 WP_001120212.1 acyl-CoA thioesterase -
HPF30_RS02390 477950..478792 + 843 WP_000504088.1 SDR family oxidoreductase -
HPF30_RS02395 478785..479765 + 981 WP_000921452.1 iron ABC transporter permease -
HPF30_RS02400 479765..480532 + 768 WP_000242357.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10273.15 Da        Isoelectric Point: 9.9840

>T26755 WP_000916178.1 NC_017365:476914-477180 [Helicobacter pylori F30]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFQDHALKGKWKPFRECHIKADILLVYLVRGDELILVR
LGSHSELF

Download         Length: 267 bp

>T26755 NC_017365:476914-477180 [Helicobacter pylori F30]
GTGTTGAAACTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATAAGGTCATTCTGTCTTTGAGAAAAAAAGAACCGCTAGACCCACAATTTCAAGATCATGCTTTAAAGGGAAAGTGGA
AACCTTTTAGGGAATGCCACATCAAAGCTGATATTTTGCTTGTGTATTTAGTGAGAGGTGATGAGCTTATTTTAGTAAGA
CTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14866.74 Da        Isoelectric Point: 6.9600

>AT26755 WP_001133872.1 NC_017365:476556-476933 [Helicobacter pylori F30]
MPNSPTKKDYTRYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELDKRDQNFKDKIDALNELLQKISQAFDDKRDCCF
RHEIPNLETQQAMRDALNKETDLIVEDFSNYSDERKRALGVETQS

Download         Length: 378 bp

>AT26755 NC_017365:476556-476933 [Helicobacter pylori F30]
ATGCCTAATTCTCCCACCAAAAAAGACTACACACGATACAGCGAAAAACAGCTTTTTAACTTAATCAATCAATTAGAGCA
AAAGATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGACAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTT
AGGCATGAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGCTAAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAATTATAGCGATGAAAGAAAAAGGGCGTTAGGTGTTGAAACTCAATCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q2PWQ0

References