Detailed information of TA system TA026755

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 476556..477180
• Replicon: chromosome
• Accession: NC_017365
• Organism: Helicobacter pylori F30

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPF30_RS02380
• Protein ID: WP_000916178.1
• Coordinates: 476914..477180 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: E6NEB5
• Locus tag: HPF30_RS02375
• Protein ID: WP_001133872.1
• Coordinates: 476556..476933 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPF30_RS02345	471615..472727	+	1113	WP_000115685.1	hydrogenase formation protein HypD	-
HPF30_RS02350	472678..473199	-	522	WP_000427272.1	hypothetical protein	-
HPF30_RS02370	473720..475945	+	2226	WP_000716304.1	Hop family adhesin BabA	-
HPF30_RS02375	476556..476933	+	378	WP_001133872.1	hypothetical protein	Antitoxin
HPF30_RS02380	476914..477180	+	267	WP_000916178.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HPF30_RS02385	477286..477810	-	525	WP_001120212.1	acyl-CoA thioesterase	-
HPF30_RS02390	477950..478792	+	843	WP_000504088.1	SDR family oxidoreductase	-
HPF30_RS02395	478785..479765	+	981	WP_000921452.1	iron ABC transporter permease	-
HPF30_RS02400	479765..480532	+	768	WP_000242357.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10273.15 Da
• Isoelectric Point: 9.9840

>T26755 WP_000916178.1 NC_017365:476914-477180 [Helicobacter pylori F30]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFQDHALKGKWKPFRECHIKADILLVYLVRGDELILVR
LGSHSELF

Nucleotide

• Length: 267 bp

>T26755 NC_017365:476914-477180 [Helicobacter pylori F30]
GTGTTGAAACTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATAAGGTCATTCTGTCTTTGAGAAAAAAAGAACCGCTAGACCCACAATTTCAAGATCATGCTTTAAAGGGAAAGTGGA
AACCTTTTAGGGAATGCCACATCAAAGCTGATATTTTGCTTGTGTATTTAGTGAGAGGTGATGAGCTTATTTTAGTAAGA
CTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14866.74 Da
• Isoelectric Point: 6.9600

>AT26755 WP_001133872.1 NC_017365:476556-476933 [Helicobacter pylori F30]
MPNSPTKKDYTRYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELDKRDQNFKDKIDALNELLQKISQAFDDKRDCCF
RHEIPNLETQQAMRDALNKETDLIVEDFSNYSDERKRALGVETQS

Nucleotide

• Length: 378 bp

>AT26755 NC_017365:476556-476933 [Helicobacter pylori F30]
ATGCCTAATTCTCCCACCAAAAAAGACTACACACGATACAGCGAAAAACAGCTTTTTAACTTAATCAATCAATTAGAGCA
AAAGATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGACAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTT
AGGCATGAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGCTAAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAATTATAGCGATGAAAGAAAAAGGGCGTTAGGTGTTGAAACTCAATCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1Q2PWQ0