Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1832306..1833901 Replicon chromosome
Accession NZ_CP115955
Organism Ralstonia pseudosolanacearum strain RUN2340

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag PG907_RS08555 Protein ID WP_193025710.1
Coordinates 1832564..1833901 (+) Length 446 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PG907_RS08550 Protein ID WP_020749234.1
Coordinates 1832306..1832560 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG907_RS08520 1828365..1829291 - 927 WP_064049931.1 muramoyltetrapeptide carboxypeptidase -
PG907_RS08525 1829288..1829839 - 552 WP_193025705.1 tRNA adenosine(34) deaminase TadA -
PG907_RS08530 1829859..1830335 - 477 WP_193025706.1 6-carboxytetrahydropterin synthase QueD -
PG907_RS08535 1830403..1831041 - 639 WP_193025707.1 7-carboxy-7-deazaguanine synthase -
PG907_RS08540 1831038..1831208 - 171 WP_193025708.1 hypothetical protein -
PG907_RS08545 1831363..1832202 + 840 WP_193025709.1 oxaloacetate decarboxylase -
PG907_RS08550 1832306..1832560 + 255 WP_020749234.1 helix-turn-helix transcriptional regulator Antitoxin
PG907_RS08555 1832564..1833901 + 1338 WP_193025710.1 type II toxin-antitoxin system HipA family toxin Toxin
PG907_RS08560 1833898..1835100 + 1203 WP_193025711.1 MFS transporter -
PG907_RS08565 1835326..1836054 + 729 WP_275760882.1 DsbA family protein -
PG907_RS08570 1836082..1836678 - 597 WP_247664382.1 RNA 2',3'-cyclic phosphodiesterase -
PG907_RS08575 1836826..1837524 - 699 WP_193034642.1 protocatechuate 3,4-dioxygenase subunit alpha -
PG907_RS08580 1837521..1838261 - 741 WP_193025714.1 protocatechuate 3,4-dioxygenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-107)

Antitoxin

Transcription regulator, HipB-like

(10-66)


Sequences

Toxin        


Download         Length: 446 a.a.        Molecular weight: 48831.87 Da        Isoelectric Point: 6.5034

>T267543 WP_193025710.1 NZ_CP115955:1832564-1833901 [Ralstonia pseudosolanacearum]
MAHPELHLWMNGEPVGIWTASRAGVPILRYDDAWLRSPNMRPLSLSLPIPAGVPELRGQVVDDYFDNLLPEAQPIRERVR
RRFSLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRIDSEPLTDSQVDALLRNLTATPALGEDAGDPDAFRISIAGA
QEKTALLRIGDAWHRPLGATPTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLTAWGLEVAHTEMARFGTSKVLAVERF
DRRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMRTCLDLLSASEHAIDDKRRFVLAQLAFWLLAATDGHAKNFS
LAIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAMALRGKNAHARLTDIHLRHWQALAAQSGVPDAFAGMLALVE
RVPAGLDQVEAILPHDFSGRVWSSVRTGVLAQTERFLTELASVTP

Download         Length: 1338 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8710.02 Da        Isoelectric Point: 10.4693

>AT267543 WP_020749234.1 NZ_CP115955:1832306-1832560 [Ralstonia pseudosolanacearum]
MESLLSSAPQLSAHLKSLRKARGLTQAQLGALLGVSQNRIADIEKDPGAVGFEQLLRILHALGAQLTLRTSAPAGGPSAA
PADW

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References