Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1570454..1571107 | Replicon | chromosome |
| Accession | NZ_CP115955 | ||
| Organism | Ralstonia pseudosolanacearum strain RUN2340 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | PG907_RS07550 | Protein ID | WP_193034500.1 |
| Coordinates | 1570922..1571107 (-) | Length | 62 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A0S4XBS4 |
| Locus tag | PG907_RS07545 | Protein ID | WP_028853163.1 |
| Coordinates | 1570454..1570855 (-) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PG907_RS07505 | 1566005..1566277 | + | 273 | WP_193034493.1 | hypothetical protein | - |
| PG907_RS07510 | 1566277..1566948 | + | 672 | WP_020748501.1 | hypothetical protein | - |
| PG907_RS07515 | 1567027..1567518 | + | 492 | WP_193034494.1 | glycoside hydrolase family protein | - |
| PG907_RS07520 | 1567518..1567826 | + | 309 | WP_193034495.1 | hypothetical protein | - |
| PG907_RS07525 | 1567829..1568104 | + | 276 | WP_193034496.1 | hypothetical protein | - |
| PG907_RS07530 | 1568104..1568649 | + | 546 | WP_193034497.1 | lysis protein | - |
| PG907_RS07535 | 1568955..1569524 | - | 570 | WP_193034499.1 | hypothetical protein | - |
| PG907_RS07540 | 1569615..1570202 | - | 588 | WP_247360096.1 | LysM domain-containing protein | - |
| PG907_RS07545 | 1570454..1570855 | - | 402 | WP_028853163.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| PG907_RS07550 | 1570922..1571107 | - | 186 | WP_193034500.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| PG907_RS07555 | 1571539..1571733 | + | 195 | WP_193025429.1 | hypothetical protein | - |
| PG907_RS07560 | 1571976..1573985 | + | 2010 | WP_193025431.1 | bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC | - |
| PG907_RS07565 | 1574219..1575568 | + | 1350 | WP_193025433.1 | trigger factor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1530078..1596043 | 65965 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 62 a.a. Molecular weight: 6915.06 Da Isoelectric Point: 10.8224
>T267542 WP_193034500.1 NZ_CP115955:c1571107-1570922 [Ralstonia pseudosolanacearum]
MQSAQLIRMLEDDGWQLVRVNGSHHHYKHPERPGLLTVPHPKKDLPIGTVRSIQKKAAGLK
MQSAQLIRMLEDDGWQLVRVNGSHHHYKHPERPGLLTVPHPKKDLPIGTVRSIQKKAAGLK
Download Length: 186 bp
Antitoxin
Download Length: 134 a.a. Molecular weight: 14752.56 Da Isoelectric Point: 4.4190
>AT267542 WP_028853163.1 NZ_CP115955:c1570855-1570454 [Ralstonia pseudosolanacearum]
MQFPIAIHKDEGSVYGVTVPDIPGVHSWGDTIDDAVRNTREAIAGHLQTLVELGEDVDVTCSTIEDLTKQDEYAGAVWAL
IDVDAEELDRTPERINVSLPRFVLKKLDRFAENRHETRSGLLARAAMELMAHG
MQFPIAIHKDEGSVYGVTVPDIPGVHSWGDTIDDAVRNTREAIAGHLQTLVELGEDVDVTCSTIEDLTKQDEYAGAVWAL
IDVDAEELDRTPERINVSLPRFVLKKLDRFAENRHETRSGLLARAAMELMAHG
Download Length: 402 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|