Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1718419..1720036 Replicon plasmid pmega
Accession NZ_CP115953
Organism Ralstonia solanacearum CFBP2957

Toxin (Protein)


Gene name hipA Uniprot ID D8P5J1
Locus tag PG903_RS22955 Protein ID WP_013208665.1
Coordinates 1718690..1720036 (+) Length 449 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID D8P5J0
Locus tag PG903_RS22950 Protein ID WP_013208664.1
Coordinates 1718419..1718685 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG903_RS22920 1713644..1714120 + 477 WP_013208658.1 RidA family protein -
PG903_RS22925 1714221..1715057 + 837 WP_013208659.1 AraC family transcriptional regulator -
PG903_RS22930 1715060..1716178 + 1119 WP_176462363.1 peptidase -
PG903_RS22935 1716217..1716600 - 384 WP_013208661.1 VOC family protein -
PG903_RS22940 1716852..1717286 + 435 WP_176462364.1 PGDYG domain-containing protein -
PG903_RS22945 1717302..1718153 - 852 WP_124982133.1 hypothetical protein -
PG903_RS22950 1718419..1718685 + 267 WP_013208664.1 helix-turn-helix transcriptional regulator Antitoxin
PG903_RS22955 1718690..1720036 + 1347 WP_013208665.1 type II toxin-antitoxin system HipA family toxin Toxin
PG903_RS22960 1720124..1721021 + 898 Protein_1352 oxygenase MpaB family protein -
PG903_RS22965 1721030..1722601 - 1572 WP_176462365.1 MDR family MFS transporter -
PG903_RS22970 1722700..1723650 - 951 WP_013208667.1 LysR family transcriptional regulator -
PG903_RS22975 1723789..1724415 + 627 WP_013208668.1 FMN-dependent NADH-azoreductase -
PG903_RS22980 1724563..1724709 - 147 WP_172830372.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cheY / cyaB / flgG / fliM / fliI / acrB / adeG / cheY / cheB / cheW / motA 1..2210741 2210741


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(159-413)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-67)


Sequences

Toxin        


Download         Length: 449 a.a.        Molecular weight: 49694.01 Da        Isoelectric Point: 7.8970

>T267541 WP_013208665.1 NZ_CP115953:1718690-1720036 [Ralstonia solanacearum CFBP2957]
MGRRSHTRVLGLWMNGTHVGRWELHPHQGDVLKYAASWVAAPEGRPLSLSLPFTPDNAPHKGPAVRAYFENLLPDSRDIR
ERIARRFQAGTTEAFDLLEQIGRDCIGALQVLPADMAPPATGDLDAEPLTEAQIAQTLRETVAPPPLGGMPEDDGHFRIS
IAGAQEKTAFLQIDGRWYRPRGATPTSHIFKLPMGLVGNMQLDLSESVENEWLCALVLRAYGLPVAHCRPLVFEDQKVLA
VERFDRMWWDRGGKRLIRLPQEDMCQATATPPHLKYEADGGPGIDRIMSLLDGSAHREADRLTLFRSQVLFWMLRAPDGH
AKNFSLALRPGGAYALTPLYDVMSAYPLLGEGPGKLSAHRIRLAMAVRSKNAHWKMQDIQRRHWLGLGQRYGLVTSDGAD
AASIVDNLVTRTPEVIRTVRAMLPEGFPQPLADRILQGLQHAADKLAG

Download         Length: 1347 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9756.26 Da        Isoelectric Point: 10.4471

>AT267541 WP_013208664.1 NZ_CP115953:1718419-1718685 [Ralstonia solanacearum CFBP2957]
MNEFIVRTPEQLPAILKGFRKQAGLSQAELATRMGMRQQTLSALERNAENVSAARLMRLLSVLGVELVLRKPDDAGEPGR
PASDQPQW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D8P5J1

Antitoxin

Source ID Structure
AlphaFold DB D8P5J0

References