Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 316274..317730 Replicon plasmid pmega
Accession NZ_CP115953
Organism Ralstonia solanacearum CFBP2957

Toxin (Protein)


Gene name rlegT Uniprot ID D8P2E1
Locus tag PG903_RS17495 Protein ID WP_013207628.1
Coordinates 316274..317119 (-) Length 282 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID D8P2E2
Locus tag PG903_RS17500 Protein ID WP_013207629.1
Coordinates 317116..317730 (-) Length 205 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG903_RS17465 311362..312477 - 1116 WP_013207622.1 FAD-dependent oxidoreductase -
PG903_RS17470 312471..313151 - 681 WP_013207623.1 cupin domain-containing protein -
PG903_RS17475 313217..313561 - 345 WP_013207624.1 carboxymuconolactone decarboxylase family protein -
PG903_RS17480 313596..313877 - 282 WP_013207625.1 hypothetical protein -
PG903_RS17485 313903..314679 - 777 WP_013207626.1 SDR family NAD(P)-dependent oxidoreductase -
PG903_RS17490 314831..315745 + 915 WP_013207627.1 transcriptional regulator GcvA -
PG903_RS17495 316274..317119 - 846 WP_013207628.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
PG903_RS17500 317116..317730 - 615 WP_013207629.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
PG903_RS17510 318417..320153 + 1737 WP_013207630.1 gamma-glutamyltransferase -
PG903_RS17515 320272..321439 - 1168 Protein_263 chitinase -
PG903_RS17520 321806..322000 - 195 WP_275719381.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cheY / cyaB / flgG / fliM / fliI / acrB / adeG / cheY / cheB / cheW / motA 1..2210741 2210741


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(35-262)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(11-55)


Sequences

Toxin        


Download         Length: 282 a.a.        Molecular weight: 31323.72 Da        Isoelectric Point: 6.3526

>T267537 WP_013207628.1 NZ_CP115953:c317119-316274 [Ralstonia solanacearum CFBP2957]
MSRNLAASIRTRLKQHANASKQDFNLTLTQYGLERLLYRLSISQHAANYLLKGALLFALWYDQPHRPTRDADLLGYGPDD
IETAVAAFREISQIEVEDGVAFEPASVRGSEIRKETGYGGVRIDLQAKLDGARIALQVDIGFGDTVTPAPETVDYPTLLD
NLPAPRLRAYPKHTVVAEKFHAVCLLGMANTRMKDYFDLWVLLTEDTLDPGELLGAAQATFTRRGLTIPEEIPAGLSDTF
ARDATKQQQWAAFLKKNRLPAMDLAQVVELLRNAFQQLQAR

Download         Length: 846 bp

Antitoxin


Download         Length: 205 a.a.        Molecular weight: 22734.60 Da        Isoelectric Point: 10.3527

>AT267537 WP_013207629.1 NZ_CP115953:c317730-317116 [Ralstonia solanacearum CFBP2957]
MMPPHQTLEQAVLALAERQPLLRARDLAKRGLPTMVLSRLVAAGKLERIARGVYSLQGRALSEHRSLAESALRVPRGVVC
LMSALRVHGIGTQAPFEVWMAIPPHTPTPSLDQPALRVVRMSGAAMTEGIEHVEIDGVPVPLFNLDKTVADCFKYRNKIG
LDVALEALRDGWSQRRLTMDRLWHYATINRVTNVMRPYLESVTT

Download         Length: 615 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D8P2E1

Antitoxin

Source ID Structure
AlphaFold DB A0A7H1KFC7

References