Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/COG3657-dnstrm_HI1420
Location 60586..61205 Replicon plasmid pmega
Accession NZ_CP115953
Organism Ralstonia solanacearum CFBP2957

Toxin (Protein)


Gene name relE Uniprot ID D8P722
Locus tag PG903_RS16460 Protein ID WP_013207426.1
Coordinates 60888..61205 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag PG903_RS16455 Protein ID WP_003262836.1
Coordinates 60586..60891 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG903_RS16435 56536..58155 + 1620 WP_042591747.1 AMP-binding protein -
PG903_RS16440 58152..58562 + 411 WP_013207423.1 thioesterase family protein -
PG903_RS16445 58592..58984 + 393 WP_013207424.1 RidA family protein -
PG903_RS16450 59051..60364 - 1314 WP_013207425.1 MFS family transporter -
PG903_RS16455 60586..60891 - 306 WP_003262836.1 putative addiction module antidote protein Antitoxin
PG903_RS16460 60888..61205 - 318 WP_013207426.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PG903_RS16465 61281..62480 - 1200 WP_013207427.1 MFS transporter -
PG903_RS16470 62607..63425 - 819 WP_013207428.1 GntR family transcriptional regulator -
PG903_RS16475 63595..64146 - 552 WP_176462251.1 helix-turn-helix domain-containing protein -
PG903_RS16480 64280..64876 + 597 WP_013207430.1 GNAT family N-acetyltransferase -
PG903_RS16485 65136..65570 + 435 WP_013207431.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cheY / cyaB / flgG / fliM / fliI / acrB / adeG / cheY / cheB / cheW / motA 1..2210741 2210741


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-92)

Antitoxin

Uncharacterized protein HI1420

(9-98)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12109.86 Da        Isoelectric Point: 6.7119

>T267535 WP_013207426.1 NZ_CP115953:c61205-60888 [Ralstonia solanacearum CFBP2957]
MLTIRTTELFDDWFCSLRDKAVQRRIQVRIDRLQMGHPGDMKAVRDGIRELRIDHGPGYRLYFVQHGVVLIVLLCGGAKS
TQEADSRRAIDLSRRLDVDDVDDVE

Download         Length: 318 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11038.72 Da        Isoelectric Point: 8.0667

>AT267535 WP_003262836.1 NZ_CP115953:c60891-60586 [Ralstonia solanacearum CFBP2957]
MTMAQRTLKTRPWDSAEHLRTEADMAAYLNACLEEAGDDPAFITHALGVVARARGMTRLARETGITREGLYKALSEDGNP
SFATMLKVIRALGIRLHAVPA

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D8P722

Antitoxin

Source ID Structure

References