Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 812394..812983 Replicon plasmid pmega
Accession NZ_CP115947
Organism Ralstonia solanacearum MolK2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PG909_RS17455 Protein ID WP_042550676.1
Coordinates 812729..812983 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PG909_RS17450 Protein ID WP_003276099.1
Coordinates 812394..812732 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG909_RS17420 808600..808938 + 339 WP_003276092.1 phage tail protein -
PG909_RS17425 808935..809612 + 678 WP_003276093.1 phage tail protein -
PG909_RS17430 809618..810214 + 597 WP_003276094.1 tail fiber assembly protein -
PG909_RS17435 810211..810912 + 702 WP_003276095.1 phage minor tail protein L -
PG909_RS17440 810914..811624 + 711 Protein_742 C40 family peptidase -
PG909_RS17445 811628..812230 + 603 WP_003276098.1 tail assembly protein -
PG909_RS17450 812394..812732 - 339 WP_003276099.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PG909_RS17455 812729..812983 - 255 WP_042550676.1 type II toxin-antitoxin system HicA family toxin Toxin
PG909_RS17460 813033..816188 + 3156 WP_003276100.1 host specificity protein J -
PG909_RS17465 816188..816499 + 312 WP_003276101.1 hypothetical protein -
PG909_RS17470 816546..817184 + 639 WP_003276102.1 hypothetical protein -
PG909_RS17475 817253..817750 + 498 WP_003276103.1 glycoside hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cheY / icl 1..2326525 2326525


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9437.96 Da        Isoelectric Point: 10.3121

>T267531 WP_042550676.1 NZ_CP115947:c812983-812729 [Ralstonia solanacearum MolK2]
MRAKHQKTLELIFSRPTPASVKWADAVALMKELGAELEDREGSRVAVFLFGQVKVMHRPHPSPDIDKGAVASIRKWFEEN
GVKP

Download         Length: 255 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12064.67 Da        Isoelectric Point: 4.8675

>AT267531 WP_003276099.1 NZ_CP115947:c812732-812394 [Ralstonia solanacearum MolK2]
MINVMNIGGHKAVIAYDPDIEMFRGEFVGLNGGADFYAADVPGLHREGELSLRVFLDECARRGVEPQKHFSGRFVLRVEG
KVHEAAAIAAAAQGVSLNQWAADVLEQAAEVA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References