Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) VapD-relB/-
Location 872254..872899 Replicon chromosome
Accession NC_017361
Organism Helicobacter pylori SouthAfrica7 (Helicobacter pylori SAfr7)

Toxin (Protein)


Gene name VapD Uniprot ID T5D7N9
Locus tag HPSA_RS04140 Protein ID WP_000271050.1
Coordinates 872254..872538 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID E8QS87
Locus tag HPSA_RS04145 Protein ID WP_001134169.1
Coordinates 872519..872899 (-) Length 127 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPSA_RS04115 867621..868727 - 1107 WP_187286394.1 glycosyltransferase family 8 protein -
HPSA_RS04120 868800..869567 - 768 WP_000242334.1 ABC transporter ATP-binding protein -
HPSA_RS04125 869567..870547 - 981 WP_000921456.1 iron ABC transporter permease -
HPSA_RS04130 870540..871394 - 855 WP_000538843.1 SDR family oxidoreductase -
HPSA_RS04135 871534..872058 + 525 WP_001135601.1 acyl-CoA thioesterase -
HPSA_RS04140 872254..872538 - 285 WP_000271050.1 endoribonuclease VapD Toxin
HPSA_RS04145 872519..872899 - 381 WP_001134169.1 hypothetical protein Antitoxin
HPSA_RS04155 873602..875827 - 2226 WP_000716245.1 Hop family adhesin BabA -
HPSA_RS04175 876558..877088 + 531 WP_041201138.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-87)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 95 a.a.        Molecular weight: 11188.74 Da        Isoelectric Point: 4.8896

>T26753 WP_000271050.1 NC_017361:c872538-872254 [Helicobacter pylori SouthAfrica7]
MYALAFDLKIEILKKEYGEPYNKAYDDLRQELELLGFEWTQGSVYVNYSKENTLAQVYKAINKLSQIEWFKKSVRDIRAF
KVEDFSDFTEIVKS

Download         Length: 285 bp

>T26753 NC_017361:c872538-872254 [Helicobacter pylori SouthAfrica7]
ATGTATGCTTTAGCGTTTGATTTAAAGATTGAGATTTTAAAAAAAGAATACGGAGAACCCTACAATAAAGCCTATGATGA
TTTAAGGCAAGAATTAGAGCTATTAGGGTTTGAATGGACTCAAGGGAGCGTTTATGTTAATTATTCTAAAGAAAACACTC
TAGCACAAGTCTATAAAGCGATCAATAAACTCTCTCAAATTGAGTGGTTTAAAAAGTCTGTTAGGGATATTAGAGCGTTT
AAGGTAGAGGACTTTAGCGATTTTACTGAGATTGTGAAATCCTAG

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 14883.87 Da        Isoelectric Point: 6.9347

>AT26753 WP_001134169.1 NC_017361:c872899-872519 [Helicobacter pylori SouthAfrica7]
MPNTTNKDYTQYSQRQLFNLMNKKEQEIEKLKRDRAYLEKKMAKELEKKDKGFTIKLEELNKILQEINKRANDCCFGHET
PNIETQQAMREALNGINLTQIDSLDDFTNELKRENSKGFENVCFSV

Download         Length: 381 bp

>AT26753 NC_017361:c872899-872519 [Helicobacter pylori SouthAfrica7]
ATGCCAAACACCACCAACAAAGATTACACCCAATACAGCCAAAGACAGCTTTTTAATCTCATGAATAAAAAAGAACAAGA
AATAGAAAAGCTAAAAAGAGATAGGGCGTATCTTGAAAAGAAAATGGCTAAAGAGCTAGAAAAAAAAGATAAAGGTTTCA
CTATCAAATTAGAAGAATTGAATAAAATCTTACAAGAGATCAACAAAAGAGCTAATGATTGTTGTTTTGGGCATGAAACC
CCAAATATTGAAACGCAACAAGCCATGAGAGAAGCGTTAAATGGAATTAATCTCACTCAAATTGATAGTTTAGATGATTT
TACAAACGAGTTAAAAAGAGAAAATAGTAAAGGTTTTGAAAATGTATGCTTTAGCGTTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 3UI3


Antitoxin

Source ID Structure
AlphaFold DB E8QS87

References