Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | VapD-relB/- |
Location | 872254..872899 | Replicon | chromosome |
Accession | NC_017361 | ||
Organism | Helicobacter pylori SouthAfrica7 (Helicobacter pylori SAfr7) |
Toxin (Protein)
Gene name | VapD | Uniprot ID | T5D7N9 |
Locus tag | HPSA_RS04140 | Protein ID | WP_000271050.1 |
Coordinates | 872254..872538 (-) | Length | 95 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | E8QS87 |
Locus tag | HPSA_RS04145 | Protein ID | WP_001134169.1 |
Coordinates | 872519..872899 (-) | Length | 127 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HPSA_RS04115 | 867621..868727 | - | 1107 | WP_187286394.1 | glycosyltransferase family 8 protein | - |
HPSA_RS04120 | 868800..869567 | - | 768 | WP_000242334.1 | ABC transporter ATP-binding protein | - |
HPSA_RS04125 | 869567..870547 | - | 981 | WP_000921456.1 | iron ABC transporter permease | - |
HPSA_RS04130 | 870540..871394 | - | 855 | WP_000538843.1 | SDR family oxidoreductase | - |
HPSA_RS04135 | 871534..872058 | + | 525 | WP_001135601.1 | acyl-CoA thioesterase | - |
HPSA_RS04140 | 872254..872538 | - | 285 | WP_000271050.1 | endoribonuclease VapD | Toxin |
HPSA_RS04145 | 872519..872899 | - | 381 | WP_001134169.1 | hypothetical protein | Antitoxin |
HPSA_RS04155 | 873602..875827 | - | 2226 | WP_000716245.1 | Hop family adhesin BabA | - |
HPSA_RS04175 | 876558..877088 | + | 531 | WP_041201138.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11188.74 Da Isoelectric Point: 4.8896
>T26753 WP_000271050.1 NC_017361:c872538-872254 [Helicobacter pylori SouthAfrica7]
MYALAFDLKIEILKKEYGEPYNKAYDDLRQELELLGFEWTQGSVYVNYSKENTLAQVYKAINKLSQIEWFKKSVRDIRAF
KVEDFSDFTEIVKS
MYALAFDLKIEILKKEYGEPYNKAYDDLRQELELLGFEWTQGSVYVNYSKENTLAQVYKAINKLSQIEWFKKSVRDIRAF
KVEDFSDFTEIVKS
Download Length: 285 bp
>T26753 NC_017361:c872538-872254 [Helicobacter pylori SouthAfrica7]
ATGTATGCTTTAGCGTTTGATTTAAAGATTGAGATTTTAAAAAAAGAATACGGAGAACCCTACAATAAAGCCTATGATGA
TTTAAGGCAAGAATTAGAGCTATTAGGGTTTGAATGGACTCAAGGGAGCGTTTATGTTAATTATTCTAAAGAAAACACTC
TAGCACAAGTCTATAAAGCGATCAATAAACTCTCTCAAATTGAGTGGTTTAAAAAGTCTGTTAGGGATATTAGAGCGTTT
AAGGTAGAGGACTTTAGCGATTTTACTGAGATTGTGAAATCCTAG
ATGTATGCTTTAGCGTTTGATTTAAAGATTGAGATTTTAAAAAAAGAATACGGAGAACCCTACAATAAAGCCTATGATGA
TTTAAGGCAAGAATTAGAGCTATTAGGGTTTGAATGGACTCAAGGGAGCGTTTATGTTAATTATTCTAAAGAAAACACTC
TAGCACAAGTCTATAAAGCGATCAATAAACTCTCTCAAATTGAGTGGTTTAAAAAGTCTGTTAGGGATATTAGAGCGTTT
AAGGTAGAGGACTTTAGCGATTTTACTGAGATTGTGAAATCCTAG
Antitoxin
Download Length: 127 a.a. Molecular weight: 14883.87 Da Isoelectric Point: 6.9347
>AT26753 WP_001134169.1 NC_017361:c872899-872519 [Helicobacter pylori SouthAfrica7]
MPNTTNKDYTQYSQRQLFNLMNKKEQEIEKLKRDRAYLEKKMAKELEKKDKGFTIKLEELNKILQEINKRANDCCFGHET
PNIETQQAMREALNGINLTQIDSLDDFTNELKRENSKGFENVCFSV
MPNTTNKDYTQYSQRQLFNLMNKKEQEIEKLKRDRAYLEKKMAKELEKKDKGFTIKLEELNKILQEINKRANDCCFGHET
PNIETQQAMREALNGINLTQIDSLDDFTNELKRENSKGFENVCFSV
Download Length: 381 bp
>AT26753 NC_017361:c872899-872519 [Helicobacter pylori SouthAfrica7]
ATGCCAAACACCACCAACAAAGATTACACCCAATACAGCCAAAGACAGCTTTTTAATCTCATGAATAAAAAAGAACAAGA
AATAGAAAAGCTAAAAAGAGATAGGGCGTATCTTGAAAAGAAAATGGCTAAAGAGCTAGAAAAAAAAGATAAAGGTTTCA
CTATCAAATTAGAAGAATTGAATAAAATCTTACAAGAGATCAACAAAAGAGCTAATGATTGTTGTTTTGGGCATGAAACC
CCAAATATTGAAACGCAACAAGCCATGAGAGAAGCGTTAAATGGAATTAATCTCACTCAAATTGATAGTTTAGATGATTT
TACAAACGAGTTAAAAAGAGAAAATAGTAAAGGTTTTGAAAATGTATGCTTTAGCGTTTGA
ATGCCAAACACCACCAACAAAGATTACACCCAATACAGCCAAAGACAGCTTTTTAATCTCATGAATAAAAAAGAACAAGA
AATAGAAAAGCTAAAAAGAGATAGGGCGTATCTTGAAAAGAAAATGGCTAAAGAGCTAGAAAAAAAAGATAAAGGTTTCA
CTATCAAATTAGAAGAATTGAATAAAATCTTACAAGAGATCAACAAAAGAGCTAATGATTGTTGTTTTGGGCATGAAACC
CCAAATATTGAAACGCAACAAGCCATGAGAGAAGCGTTAAATGGAATTAATCTCACTCAAATTGATAGTTTAGATGATTT
TACAAACGAGTTAAAAAGAGAAAATAGTAAAGGTTTTGAAAATGTATGCTTTAGCGTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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