Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 2759853..2760486 Replicon chromosome
Accession NZ_CP115946
Organism Ralstonia solanacearum MolK2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PG909_RS12110 Protein ID WP_042550838.1
Coordinates 2759853..2760266 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID F6FXL0
Locus tag PG909_RS12115 Protein ID WP_003263271.1
Coordinates 2760253..2760486 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG909_RS12090 2755191..2756927 + 1737 WP_003273655.1 ABC transporter substrate-binding protein -
PG909_RS12095 2757098..2758594 + 1497 WP_003273657.1 glycerol kinase GlpK -
PG909_RS12100 2758670..2759041 - 372 WP_003263275.1 hypothetical protein -
PG909_RS12105 2759252..2759878 + 627 WP_042550837.1 DUF1415 family protein -
PG909_RS12110 2759853..2760266 - 414 WP_042550838.1 PIN domain-containing protein Toxin
PG909_RS12115 2760253..2760486 - 234 WP_003263271.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
PG909_RS12120 2760544..2762151 - 1608 WP_042550839.1 glucan biosynthesis protein -
PG909_RS12125 2762347..2763615 + 1269 WP_155402184.1 AGE family epimerase/isomerase -
PG909_RS12130 2763623..2764912 + 1290 WP_003263268.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-116)

Antitoxin

SpoVT-AbrB domain

(5-40)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14871.19 Da        Isoelectric Point: 5.9701

>T267529 WP_042550838.1 NZ_CP115946:c2760266-2759853 [Ralstonia solanacearum MolK2]
MPAAEAFFDSNIVLYLLSADAAKADAAEALLMAGGVVSVQVLNETTHVMRRKLAMPWHAIEAVQEAVRAQCRVEPLTVET
HDLGRHLAQRYGLSVYDALIVAAASLAGCRVLYSEDMQHGLVIEQRLRVVNPFVASA

Download         Length: 414 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8664.82 Da        Isoelectric Point: 8.7288

>AT267529 WP_003263271.1 NZ_CP115946:c2760486-2760253 [Ralstonia solanacearum MolK2]
MQVSKWGNSLAIRLPAAVVEALGLHEGDDVEVVVAGERSFGVRRKRSARELFERLHQYRGKLPADFIFERDDANARG

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB F6FXL0

References