Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1977368..1978985 Replicon chromosome
Accession NZ_CP115946
Organism Ralstonia solanacearum MolK2

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag PG909_RS08515 Protein ID WP_042551107.1
Coordinates 1977639..1978985 (+) Length 449 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PG909_RS08510 Protein ID WP_003265838.1
Coordinates 1977368..1977634 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG909_RS08480 1972588..1973064 + 477 WP_003277350.1 RidA family protein -
PG909_RS08485 1973165..1974001 + 837 WP_003277351.1 AraC family transcriptional regulator -
PG909_RS08490 1974004..1975122 + 1119 WP_003277352.1 dienelactone hydrolase protein -
PG909_RS08495 1975161..1975544 - 384 WP_003277353.1 VOC family protein -
PG909_RS08500 1975803..1976237 + 435 WP_003277354.1 PGDYG domain-containing protein -
PG909_RS08505 1976253..1977104 - 852 WP_003277355.1 hypothetical protein -
PG909_RS08510 1977368..1977634 + 267 WP_003265838.1 helix-turn-helix transcriptional regulator Antitoxin
PG909_RS08515 1977639..1978985 + 1347 WP_042551107.1 type II toxin-antitoxin system HipA family toxin Toxin
PG909_RS08520 1979080..1979976 + 897 WP_003277357.1 oxygenase MpaB family protein -
PG909_RS08525 1979980..1981551 - 1572 WP_049279714.1 MDR family MFS transporter -
PG909_RS08530 1981644..1982594 - 951 WP_003277361.1 LysR family transcriptional regulator -
PG909_RS08535 1982738..1983364 + 627 WP_003265843.1 FMN-dependent NADH-azoreductase -
PG909_RS08540 1983524..1983670 - 147 WP_003277363.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(159-412)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-67)


Sequences

Toxin        


Download         Length: 449 a.a.        Molecular weight: 49628.89 Da        Isoelectric Point: 7.9080

>T267528 WP_042551107.1 NZ_CP115946:1977639-1978985 [Ralstonia solanacearum MolK2]
MGRRSHTRALGLWMNGTHVGRWELHPHQGDVLKYAASWVAAPEGRPLSLSLPFTPDNAPHKGPAVRAYFENLLPDSRDIR
ERIARRFQAGTTEAFDLLEQIGRDCIGALQVLPADMAPPATGDIDAEPLTEAQIAQTLRETVAPPPLGGMPEDDGHFRIS
IAGAQEKTAFLQIDGHWYRPRGATPTSHIFKLPMGLVGNMQLDLSESVENEWLCALVLRAYGLPVAHCRPLVFEDQKVLA
VERFDRMWWDRGGKRLIRLPQEDMCQATATPPHLKYEADGGPGIDRIMGLLDGSAHREADRLTLFRSQVLFWMLRAPDGH
AKNFSLALRPGGAYALTPLYDVMSAYPLLGEGPGKLSPHRIRLAMAVRSKNAHWKMQDIQRRHWLGLGQRYGIVTSDGAD
AASIVDNLVARTPEVTRTVRAMLPEGFPQPLADRILQGLRHAADKLAG

Download         Length: 1347 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9668.20 Da        Isoelectric Point: 10.9487

>AT267528 WP_003265838.1 NZ_CP115946:1977368-1977634 [Ralstonia solanacearum MolK2]
MNEFIVRTPEQLPAILKGFRKQAGLSQAELAARMGMRQQTLSALERNAENVSAGRLMRLLSVLGVELVLRKPDAAGEPGR
PASDQPQW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References