Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1317784..1319401 Replicon plasmid pmega
Accession NZ_CP115945
Organism Ralstonia syzygii R24

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag PG906_RS23045 Protein ID WP_197334414.1
Coordinates 1318055..1319401 (+) Length 449 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PG906_RS23040 Protein ID WP_013210321.1
Coordinates 1317784..1318050 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG906_RS23010 1313036..1313512 + 477 WP_197334418.1 RidA family protein -
PG906_RS23015 1313615..1314454 + 840 WP_197334417.1 AraC family transcriptional regulator -
PG906_RS23020 1314457..1315575 + 1119 WP_197334416.1 peptidase -
PG906_RS23025 1315602..1315985 - 384 WP_013210318.1 VOC family protein -
PG906_RS23030 1316225..1316668 + 444 WP_197334415.1 PGDYG domain-containing protein -
PG906_RS23035 1316684..1317589 - 906 WP_048817081.1 hypothetical protein -
PG906_RS23040 1317784..1318050 + 267 WP_013210321.1 helix-turn-helix transcriptional regulator Antitoxin
PG906_RS23045 1318055..1319401 + 1347 WP_197334414.1 type II toxin-antitoxin system HipA family toxin Toxin
PG906_RS23050 1319478..1320374 + 897 WP_197334413.1 oxygenase MpaB family protein -
PG906_RS23055 1320378..1321946 - 1569 WP_197334412.1 MDR family MFS transporter -
PG906_RS23060 1322039..1322989 - 951 WP_197334411.1 LysR family transcriptional regulator -
PG906_RS23065 1323129..1323755 + 627 WP_197334410.1 FMN-dependent NADH-azoreductase -
PG906_RS23070 1323889..1324035 - 147 WP_197334409.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cheY / cyaB / flgC / flgG / fliM / fliG / fliI / adeG / cheY / cheB / cheW / motA 1..1751279 1751279


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-67)


Sequences

Toxin        


Download         Length: 449 a.a.        Molecular weight: 49514.76 Da        Isoelectric Point: 7.6087

>T267525 WP_197334414.1 NZ_CP115945:1318055-1319401 [Ralstonia syzygii R24]
MGRRSHTRALGLWMNGTHVGHWELHPHQGDVLKYAASWVAAPEGRPLSLSLPFTPDNAPYKGPAVRAYFENLLPDSRDIR
ERIARRFQAGTTEAFDLLEQIGRDCIGALQVLPAGMAPAGIGDLDAEPLTEAQIAQTLRETVAPAPLGGMPEDDGNFRIS
IAGAQEKTAFLQIDGRWYRPRGATPTSHIFKLPMGRVGNMKLDLSESVENEWLCSLVLRAYGLPIAHCRPLVFEDQKVLA
VERFDRMWRDHRGRQLIRLPQEDMCQATATPPHLKYEADGGPGIDRIMGLLDGSAHRDADRLMLFQSQVLFWMLCAPDGH
AKNFSLALRPGGAYALTPLYDVMSAYPLLGEGPGKLSPHRIRLAMAVRSKNPHWKMQDVQRRHWLGLGQRHGIATPEGGH
AAAIVDSLVARTPEVVRTVRALLPEDFPQPLADSILQGLQSAADRLAQ

Download         Length: 1347 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9743.27 Da        Isoelectric Point: 11.3495

>AT267525 WP_013210321.1 NZ_CP115945:1317784-1318050 [Ralstonia syzygii R24]
MNEFIVRTPEQLPAILKGFRKQAGLSQAELAARMGMRQQTLSALERNAENVSAGRLMRLLSVLGVELVLRKPDASGERGR
PASDQPQW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References