Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 1117331..1117955 Replicon chromosome
Accession NC_017360
Organism Helicobacter pylori 35A

Toxin (Protein)


Gene name relE Uniprot ID E6S2G8
Locus tag HMPREF4655_RS05450 Protein ID WP_000916177.1
Coordinates 1117331..1117597 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID E6S2G9
Locus tag HMPREF4655_RS05455 Protein ID WP_001133877.1
Coordinates 1117578..1117955 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMPREF4655_RS05430 1113984..1114751 - 768 WP_000242364.1 ABC transporter ATP-binding protein -
HMPREF4655_RS05435 1114751..1115731 - 981 WP_000921438.1 iron ABC transporter permease -
HMPREF4655_RS05440 1115724..1116572 - 849 WP_000504110.1 SDR family oxidoreductase -
HMPREF4655_RS05445 1116712..1117236 + 525 WP_001135614.1 acyl-CoA thioesterase -
HMPREF4655_RS05450 1117331..1117597 - 267 WP_000916177.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HMPREF4655_RS05455 1117578..1117955 - 378 WP_001133877.1 hypothetical protein Antitoxin
HMPREF4655_RS05460 1118547..1120781 - 2235 WP_000716215.1 Hop family adhesin BabA -
HMPREF4655_RS05480 1121302..1121823 + 522 WP_000427273.1 hypothetical protein -
HMPREF4655_RS05485 1121774..1122886 - 1113 WP_000115675.1 hydrogenase formation protein HypD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10331.19 Da        Isoelectric Point: 9.6561

>T26752 WP_000916177.1 NC_017360:c1117597-1117331 [Helicobacter pylori 35A]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFQDHALKGKWKPFRECHIKADILLVYLVRDDELILVR
LGSHSELF

Download         Length: 267 bp

>T26752 NC_017360:c1117597-1117331 [Helicobacter pylori 35A]
GTGTTAAAACTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAACGGGTTTGATGATAGCGTTTT
GAATAAGGTCATTCTGTCTTTGAGAAAAAAAGAACCGCTAGACCCACAATTTCAAGATCATGCTTTAAAAGGAAAGTGGA
AACCTTTTAGGGAATGCCACATCAAAGCTGATATTTTGCTTGTGTATTTAGTGAGAGATGATGAGCTTATTTTAGTAAGA
CTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14616.66 Da        Isoelectric Point: 9.6856

>AT26752 WP_001133877.1 NC_017360:c1117955-1117578 [Helicobacter pylori 35A]
MPNSPTKKDYTRYSEKQLFNLINQLEQKIKKMQNDRVSFKEKMAKELDKRDQNFKDKIDALNELLQKISQAFDGKRGCCL
GHKIPNLETQQAMRDALNKETDLIVEDFSSYSDERKRALGVKTQS

Download         Length: 378 bp

>AT26752 NC_017360:c1117955-1117578 [Helicobacter pylori 35A]
ATGCCTAATTCTCCCACCAAAAAAGACTACACACGATACAGCGAAAAACAGCTTTTTAACTTAATCAACCAATTAGAGCA
AAAAATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGACAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGGTAAAAGAGGTTGTTGTTTG
GGGCACAAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGCTCAACAAAGAAACTGATTTGATTGTTGAGGA
TTTTTCTAGTTATAGCGATGAAAGAAAAAGGGCGTTAGGTGTTAAAACTCAATCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A402E178

Antitoxin

Source ID Structure
AlphaFold DB E6S2G9

References