Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1242552..1243146 Replicon chromosome
Accession NZ_CP115944
Organism Ralstonia syzygii R24

Toxin (Protein)


Gene name hicA Uniprot ID G3A6N4
Locus tag PG906_RS06175 Protein ID WP_016721901.1
Coordinates 1242883..1243146 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PG906_RS06170 Protein ID WP_197332943.1
Coordinates 1242552..1242890 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG906_RS06140 1238976..1239314 + 339 WP_197332937.1 phage tail protein -
PG906_RS06145 1239311..1239946 + 636 WP_197332938.1 phage tail protein -
PG906_RS06150 1239952..1240548 + 597 WP_197332939.1 tail fiber assembly protein -
PG906_RS06155 1240545..1241246 + 702 WP_197332940.1 phage minor tail protein L -
PG906_RS06160 1241248..1241958 + 711 WP_197332941.1 C40 family peptidase -
PG906_RS06165 1241962..1242555 + 594 WP_197332942.1 tail assembly protein -
PG906_RS06170 1242552..1242890 - 339 WP_197332943.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PG906_RS06175 1242883..1243146 - 264 WP_016721901.1 type II toxin-antitoxin system HicA family toxin Toxin
PG906_RS06180 1243199..1246354 + 3156 WP_275794576.1 host specificity protein J -
PG906_RS06185 1246691..1247347 + 657 WP_197332944.1 hypothetical protein -
PG906_RS06190 1247418..1247909 + 492 WP_197332945.1 glycoside hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1208141..1252679 44538


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(56-105)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 9834.30 Da        Isoelectric Point: 8.7458

>T267519 WP_016721901.1 NZ_CP115944:c1243146-1242883 [Ralstonia syzygii R24]
MKAKHKKTLDLIFSRPTPAGVKWNDLVGLLVELGAEITEREGSRVAVFLFNQVKVMHRPHPSPDVDKGAVASIRKWLEDN
ATEWNNE

Download         Length: 264 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12164.76 Da        Isoelectric Point: 4.8891

>AT267519 WP_197332943.1 NZ_CP115944:c1242890-1242552 [Ralstonia syzygii R24]
MNNVMIIGGEKAVISFDPELEMFRGEFIGLNGGADFYASDVAGLHREGELSLHTFMEECVRRGVEPRRSFSGKFVLRTSE
KTHEAAAIAAAAHGVSLNQWVSDVIEQAAIPA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3A6N4

Antitoxin

Source ID Structure

References