Detailed information of TA system TA267517

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): rlegTA/AbiEii-AbiEi
• Location: 3099302..3100821
• Replicon: chromosome
• Accession: NZ_CP115941
• Organism: Ralstonia syzygii strain BDBR229

Toxin (Protein)

• Gene name: rlegT
• Uniprot ID: -
• Locus tag: PG904_RS14220
• Protein ID: WP_078222737.1
• Coordinates: 3099898..3100821 (+)
• Length: 308 a.a.

Antitoxin (Protein)

• Gene name: rlegA
• Uniprot ID: -
• Locus tag: PG904_RS14215
• Protein ID: WP_078222738.1
• Coordinates: 3099302..3099901 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PG904_RS14210	3095132..3099196	-	4065	WP_257788438.1	helix-turn-helix transcriptional regulator	-
PG904_RS14215	3099302..3099901	+	600	WP_078222738.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
PG904_RS14220	3099898..3100821	+	924	WP_078222737.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
PG904_RS14225	3101068..3102278	+	1211	WP_099091583.1	IS3 family transposase	-
PG904_RS14230	3102530..3103801	-	1272	WP_172840182.1	IS256 family transposase	-
PG904_RS14235	3104383..3105654	+	1272	WP_172840182.1	IS256 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3095132..3106135	11003
	-	flank	IS/Tn	-	-	3093554..3094876	1322

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (39-275)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-50)

Sequences

Toxin

Protein

• Length: 308 a.a.
• Molecular weight: 34682.77 Da
• Isoelectric Point: 5.9899

>T267517 WP_078222737.1 NZ_CP115941:3099898-3100821 [Ralstonia syzygii]
MNTTAPKHSATSIRARLFNHAKERGDDFQRVLTRYAIERLLFRLSQTEAVERYVLKGAMLFVTWPEHVFRPSGDLDLLGQ
GNPDPDAITELFTRICQVDVADDGIVFEPATLKVEPVREADKYQGVRLSLKGELAKAVIHVQVDIGFGDYVYPPPKYHIF
PSLLQDLPAANILMYPPETVVAEKFEAMIRFGEANGRIKDFHDMWVMTRTFSFDMPTLVEAVGGTLRRRETAIPTEMPAG
LTETFAKVAEERGLWSGFLRRNPPTLQPPPFADLQEELRRFFGPVITNLALPEGAKGRWDPDAGAWR

Nucleotide

• Length: 924 bp

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22406.09 Da
• Isoelectric Point: 9.9958

>AT267517 WP_078222738.1 NZ_CP115941:3099302-3099901 [Ralstonia syzygii]
MTYRERALSLIRDRGIARARDFKAAAIPLVYLKRLTDAGDLVRLGRGLYQDPERVGEDIAHDLAEAARLVPNGVISLISA
LRHHQLTTQLPHAVWITIPHKARTPNLQGLRLEIIRATDEVLTAGVEHIRVEGVDVPIYCVAKTIADCFKHRRHVGEDVA
IEALRDALRQKKTTVSELMKYAAIDRVAKRIEPYIKAMQ

Nucleotide

• Length: 600 bp