Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2607488..2609105 Replicon chromosome
Accession NZ_CP115941
Organism Ralstonia syzygii strain BDBR229

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag PG904_RS12265 Protein ID WP_078222912.1
Coordinates 2607759..2609105 (+) Length 449 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PG904_RS12260 Protein ID WP_078222913.1
Coordinates 2607488..2607754 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG904_RS12230 2602748..2603224 + 477 WP_078222917.1 RidA family protein -
PG904_RS12235 2603327..2604166 + 840 WP_078222916.1 AraC family transcriptional regulator -
PG904_RS12240 2604169..2605278 + 1110 WP_078222915.1 peptidase -
PG904_RS12245 2605305..2605688 - 384 WP_013210318.1 VOC family protein -
PG904_RS12250 2605928..2606371 + 444 WP_172840169.1 PGDYG domain-containing protein -
PG904_RS12255 2606387..2607292 - 906 WP_078222914.1 hypothetical protein -
PG904_RS12260 2607488..2607754 + 267 WP_078222913.1 helix-turn-helix transcriptional regulator Antitoxin
PG904_RS12265 2607759..2609105 + 1347 WP_078222912.1 type II toxin-antitoxin system HipA family toxin Toxin
PG904_RS12270 2609182..2610078 + 897 WP_078222911.1 oxygenase MpaB family protein -
PG904_RS12275 2610082..2611650 - 1569 WP_075467852.1 MDR family MFS transporter -
PG904_RS12280 2611743..2612693 - 951 WP_013210325.1 LysR family transcriptional regulator -
PG904_RS12285 2612833..2613459 + 627 WP_013210326.1 FMN-dependent NADH-azoreductase -
PG904_RS12290 2613593..2613739 - 147 WP_162899024.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(11-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-67)


Sequences

Toxin        


Download         Length: 449 a.a.        Molecular weight: 49831.16 Da        Isoelectric Point: 7.5915

>T267516 WP_078222912.1 NZ_CP115941:2607759-2609105 [Ralstonia syzygii]
MGRRSHTRALGLWMNGTHVGHWELHPHQGDVLKYAASWVAAPEGRPLSLSLPFTPDNAPYKGPAVRAYFENLLPDSRDIR
ERIARRFQAGTTEAFDLLEQIGRDCIGALQVLPADMAPASIGDIDAEPLTEAQIAQTLRETVAPPPLGGMPEDDGNFRIS
IAGAQEKTAFLQIDERWYRPRGATPTSHIFKLPMGRVGNMKLDLSESVENEWLCSLVLRAYGLPIAHCQPLVFEDQKVLA
VERFDRMWRDHRGRQLIRLPQEDMCQATATPPHLKYEADGGPGIDRIMGLLDGSARRDADRLMLFQSQVLFWMLCAPDGH
AKNFSLALRPGGAYALTPLYDVMSAYPLLGEGPGKLSPHRIRLAMAVRSKNPHWKMQDVQRRHWLGLGQRHGIVTPEGGH
AAAIVDSLVARTPEVIRTVRALLPEDFPQPLADRILRGLQSAADRLAQ

Download         Length: 1347 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9773.30 Da        Isoelectric Point: 11.3495

>AT267516 WP_078222913.1 NZ_CP115941:2607488-2607754 [Ralstonia syzygii]
MNEFIVRTPEQLPAILKGFRKQAGLSQAELATRMGMRQQTLSALERNAENVSAGRLMRLLSVLGVELVLRKPDASGERGR
PASDQPQW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References