Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 997406..997995 Replicon chromosome
Accession NZ_CP115941
Organism Ralstonia syzygii strain BDBR229

Toxin (Protein)


Gene name hicA Uniprot ID A0A1U9VH68
Locus tag PG904_RS04720 Protein ID WP_072633588.1
Coordinates 997741..997995 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1U9VFS6
Locus tag PG904_RS04715 Protein ID WP_028853154.1
Coordinates 997406..997744 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG904_RS04685 993706..994044 + 339 WP_078222081.1 phage tail protein -
PG904_RS04690 994041..994718 + 678 WP_078222080.1 phage tail protein -
PG904_RS04695 994724..995320 + 597 WP_078222079.1 tail fiber assembly protein -
PG904_RS04700 995317..996018 + 702 WP_078222078.1 phage minor tail protein L -
PG904_RS04705 996020..996730 + 711 WP_072633587.1 C40 family peptidase -
PG904_RS04710 996734..997336 + 603 WP_072633645.1 tail assembly protein -
PG904_RS04715 997406..997744 - 339 WP_028853154.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PG904_RS04720 997741..997995 - 255 WP_072633588.1 type II toxin-antitoxin system HicA family toxin Toxin
PG904_RS04725 998046..1001201 + 3156 WP_078222077.1 host specificity protein J -
PG904_RS04730 1001538..1002194 + 657 WP_078222075.1 hypothetical protein -
PG904_RS04735 1002263..1002754 + 492 WP_011001641.1 glycoside hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 966822..1007250 40428


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9488.05 Da        Isoelectric Point: 10.3121

>T267514 WP_072633588.1 NZ_CP115941:c997995-997741 [Ralstonia syzygii]
MKAKHQKTLELIFSRPTPAGVKWADAVTLMRELGAELEEREGSRVAVFLFGQVKVMHRPHPSPDMDKGAVASMRKWFEEN
GVKP

Download         Length: 255 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 11968.58 Da        Isoelectric Point: 5.1375

>AT267514 WP_028853154.1 NZ_CP115941:c997744-997406 [Ralstonia syzygii]
MINVMNIGGHKAVIAYDPDIEMFRGEFVGLNGGADFYAADVTGLHREGELSLRVFLEECARRGVEPQKHFSGKFVLRVEG
KVHEAAAIAAAAQGVSLNQWAAGVLEQAAEAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9VH68

Antitoxin

Source ID Structure
AlphaFold DB A0A1U9VFS6

References