Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 2972408..2972937 Replicon chromosome
Accession NZ_CP115936
Organism Streptomyces goshikiensis strain CGMCC 4.1796

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag PET44_RS12840 Protein ID WP_271244220.1
Coordinates 2972680..2972937 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4VEP7
Locus tag PET44_RS12835 Protein ID WP_008743448.1
Coordinates 2972408..2972683 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PET44_RS12820 (PET44_12820) 2968566..2969936 - 1371 WP_271244219.1 nitrate/nitrite transporter -
PET44_RS12825 (PET44_12825) 2970034..2970996 - 963 WP_271245150.1 LysR family transcriptional regulator -
PET44_RS12830 (PET44_12830) 2971084..2972379 + 1296 WP_086025432.1 MFS transporter -
PET44_RS12835 (PET44_12835) 2972408..2972683 + 276 WP_008743448.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PET44_RS12840 (PET44_12840) 2972680..2972937 + 258 WP_271244220.1 Txe/YoeB family addiction module toxin Toxin
PET44_RS12850 (PET44_12850) 2973474..2973959 - 486 WP_008743446.1 SsrA-binding protein SmpB -
PET44_RS12855 (PET44_12855) 2973978..2975180 - 1203 WP_037797668.1 S41 family peptidase -
PET44_RS12860 (PET44_12860) 2975248..2976213 - 966 WP_008743442.1 permease-like cell division protein FtsX -
PET44_RS12865 (PET44_12865) 2976230..2976919 - 690 WP_008743441.1 cell division ATP-binding protein FtsE -
PET44_RS12870 (PET44_12870) 2977149..2977340 + 192 WP_008743440.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-71)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10175.56 Da        Isoelectric Point: 9.8313

>T267513 WP_271244220.1 NZ_CP115936:2972680-2972937 [Streptomyces goshikiensis]
VRSVHFDPAAWEDFLFWLSSDRKTARRITRLIGEIQRDPFTGIGKPEPLKGELTGYWSRRIDDEHRLVYRADDKEVKVLK
ARYHY

Download         Length: 258 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10079.26 Da        Isoelectric Point: 4.5098

>AT267513 WP_008743448.1 NZ_CP115936:2972408-2972683 [Streptomyces goshikiensis]
MSISASEARATLFPLIERVNTDHDPVRITSKNGDAVLMSADDYDSWQETVYLLRSPANAQRLMEAVARDREGAPAVTKSM
EELRRLAGGEE

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3N6GF48

References