Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4767043..4767559 Replicon chromosome
Accession NZ_CP115930
Organism Klebsiella pneumoniae subsp. pneumoniae strain 43UC01

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag DLD89_RS23660 Protein ID WP_002886902.1
Coordinates 4767043..4767327 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag DLD89_RS23665 Protein ID WP_002886901.1
Coordinates 4767317..4767559 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DLD89_RS23635 (DLD89_23630) 4762527..4762835 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
DLD89_RS23640 (DLD89_23635) 4762920..4763093 + 174 WP_002886906.1 hypothetical protein -
DLD89_RS23645 (DLD89_23640) 4763096..4763839 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
DLD89_RS23650 (DLD89_23645) 4764196..4766334 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
DLD89_RS23655 (DLD89_23650) 4766575..4767039 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
DLD89_RS23660 (DLD89_23655) 4767043..4767327 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DLD89_RS23665 (DLD89_23660) 4767317..4767559 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DLD89_RS23670 (DLD89_23665) 4767637..4769547 - 1911 WP_004152270.1 PRD domain-containing protein -
DLD89_RS23675 (DLD89_23670) 4769570..4770724 - 1155 WP_002886900.1 lactonase family protein -
DLD89_RS23680 (DLD89_23675) 4770790..4771530 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T267508 WP_002886902.1 NZ_CP115930:c4767327-4767043 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT267508 WP_002886901.1 NZ_CP115930:c4767559-4767317 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References