Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2629524..2631112 Replicon chromosome
Accession NZ_CP115930
Organism Klebsiella pneumoniae subsp. pneumoniae strain 43UC01

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag DLD89_RS13035 Protein ID WP_002904792.1
Coordinates 2629524..2630846 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag DLD89_RS13040 Protein ID WP_002904790.1
Coordinates 2630846..2631112 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DLD89_RS13020 (DLD89_13020) 2624580..2627081 + 2502 WP_004151634.1 fimbria/pilus outer membrane usher protein -
DLD89_RS13025 (DLD89_13025) 2627069..2628073 + 1005 WP_002904798.1 fimbrial protein -
DLD89_RS13030 (DLD89_13030) 2628215..2629507 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
DLD89_RS13035 (DLD89_13035) 2629524..2630846 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
DLD89_RS13040 (DLD89_13040) 2630846..2631112 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
DLD89_RS13045 (DLD89_13045) 2631378..2631704 - 327 WP_002904788.1 hydroxyisourate hydrolase -
DLD89_RS13050 (DLD89_13050) 2631701..2632201 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
DLD89_RS13055 (DLD89_13055) 2632179..2633558 - 1380 WP_002904785.1 nucleobase:cation symporter-2 family protein -
DLD89_RS13060 (DLD89_13060) 2633904..2635058 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
DLD89_RS13065 (DLD89_13065) 2635039..2635962 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T267505 WP_002904792.1 NZ_CP115930:c2630846-2629524 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT267505 WP_002904790.1 NZ_CP115930:c2631112-2630846 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References