Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 871851..872508 Replicon chromosome
Accession NZ_CP115930
Organism Klebsiella pneumoniae subsp. pneumoniae strain 43UC01

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag DLD89_RS04405 Protein ID WP_002916310.1
Coordinates 872098..872508 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag DLD89_RS04400 Protein ID WP_002916312.1
Coordinates 871851..872117 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DLD89_RS04375 (DLD89_04375) 867007..868440 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
DLD89_RS04380 (DLD89_04380) 868559..869287 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
DLD89_RS04385 (DLD89_04385) 869337..869648 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
DLD89_RS04390 (DLD89_04390) 869812..870471 + 660 WP_002916317.1 hemolysin III family protein -
DLD89_RS04395 (DLD89_04395) 870622..871605 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
DLD89_RS04400 (DLD89_04400) 871851..872117 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
DLD89_RS04405 (DLD89_04405) 872098..872508 + 411 WP_002916310.1 protein YgfX Toxin
DLD89_RS04410 (DLD89_04410) 872515..873036 - 522 WP_002916308.1 flavodoxin FldB -
DLD89_RS04415 (DLD89_04415) 873137..874033 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
DLD89_RS04420 (DLD89_04420) 874056..874769 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DLD89_RS04425 (DLD89_04425) 874775..876508 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T267500 WP_002916310.1 NZ_CP115930:872098-872508 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT267500 WP_002916312.1 NZ_CP115930:871851-872117 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References