Detailed information of TA system TA026750

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 956370..957003
• Replicon: chromosome
• Accession: NC_017358
• Organism: Helicobacter pylori Cuz20

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPCU_RS04560
• Protein ID: WP_000916172.1
• Coordinates: 956370..956636 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HPCU_RS04565
• Protein ID: WP_001133852.1
• Coordinates: 956617..957003 (-)
• Length: 129 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPCU_RS04540	953019..953786	-	768	WP_000242371.1	ABC transporter ATP-binding protein	-
HPCU_RS04545	953786..954766	-	981	WP_000921444.1	iron ABC transporter permease	-
HPCU_RS04550	954759..955601	-	843	WP_000504119.1	SDR family oxidoreductase	-
HPCU_RS04555	955742..956266	+	525	WP_001120215.1	acyl-CoA thioesterase	-
HPCU_RS04560	956370..956636	-	267	WP_000916172.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HPCU_RS04565	956617..957003	-	387	WP_001133852.1	hypothetical protein	Antitoxin
HPCU_RS04570	957225..959441	-	2217	WP_000716207.1	outer membrane beta-barrel protein	-
HPCU_RS04585	959768..960396	+	629	Protein_887	hypothetical protein	-
HPCU_RS04590	960347..961459	-	1113	WP_000115671.1	hydrogenase formation protein HypD	-
HPCU_RS04595	961482..961718	-	237	WP_000335457.1	HypC/HybG/HupF family hydrogenase formation chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10318.14 Da
• Isoelectric Point: 8.0602

>T26750 WP_000916172.1 NC_017358:c956636-956370 [Helicobacter pylori Cuz20]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVVLTLRKKEPLDPQFQDHALKGKWKPFRECHIKADILLVYLVKDDELILLR
LGSHSELF

Nucleotide

• Length: 267 bp

>T26750 NC_017358:c956636-956370 [Helicobacter pylori Cuz20]
GTGTTAAAACTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTGCTTTTGAATGGGTTTGATGATAGCGTTTT
GAATGAAGTCGTTCTAACCCTAAGAAAAAAAGAACCGCTAGACCCACAATTTCAAGATCATGCTTTAAAGGGAAAGTGGA
AGCCTTTTAGGGAATGCCACATCAAAGCTGATATTTTGCTTGTGTATCTAGTGAAAGATGATGAGCTTATTTTGTTAAGG
CTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 129 a.a.
• Molecular weight: 14944.91 Da
• Isoelectric Point: 5.9695

>AT26750 WP_001133852.1 NC_017358:c957003-956617 [Helicobacter pylori Cuz20]
MPNSPTKKDCTQYSEKQLFNLINQLERKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNELLQKISQVFDDKRDCCL
GHEIPNLETQQAMRDALNGENLETDLIVEDFSSYSDERKKALGVKTQS

Nucleotide

• Length: 387 bp

>AT26750 NC_017358:c957003-956617 [Helicobacter pylori Cuz20]
ATGCCTAACTCTCCCACCAAAAAAGACTGCACGCAATACAGCGAAAAACAGCTTTTTAACTTAATCAATCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGTTTTTGACGATAAAAGAGATTGTTGTTTG
GGGCATGAAATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGTTAAATGGCGAGAACTTAGAAACCGATTTGAT
TGTTGAGGATTTTTCTAGTTATAGCGATGAGAGAAAAAAGGCGTTAGGTGTTAAAACTCAATCTTAA