Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 284296..284966 Replicon plasmid pAtK224a
Accession NZ_CP115926
Organism Agrobacterium fabacearum strain K224

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6L41_RS24190 Protein ID WP_173994792.1
Coordinates 284547..284966 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID F0LGD9
Locus tag G6L41_RS24185 Protein ID WP_003517203.1
Coordinates 284296..284550 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6L41_RS24175 (G6L41_024175) 281784..282785 + 1002 WP_003517209.1 sensor histidine kinase -
G6L41_RS24180 (G6L41_024180) 283320..283925 - 606 WP_065703247.1 J domain-containing protein -
G6L41_RS24185 (G6L41_024185) 284296..284550 + 255 WP_003517203.1 plasmid stabilization protein Antitoxin
G6L41_RS24190 (G6L41_024190) 284547..284966 + 420 WP_173994792.1 type II toxin-antitoxin system VapC family toxin Toxin
G6L41_RS24195 (G6L41_024195) 285106..286002 - 897 WP_013637432.1 dihydrodipicolinate synthase family protein -
G6L41_RS24200 (G6L41_024200) 286035..286916 - 882 WP_173994791.1 SMP-30/gluconolactonase/LRE family protein -
G6L41_RS24205 (G6L41_024205) 286973..287692 - 720 WP_003517195.1 FCD domain-containing protein -
G6L41_RS24210 (G6L41_024210) 287992..289941 + 1950 WP_060643031.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..485342 485342


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15149.38 Da        Isoelectric Point: 5.8701

>T267495 WP_173994792.1 NZ_CP115926:284547-284966 [Agrobacterium fabacearum]
MILLDTNVISEPWKPVPDEAVIAWLDAQAVETLFISAITIAELRFGIAAMPSGRRQTILRDRLEGEVLPHFSGRILSFDL
TTSQFYSELMARARATRKAIGTADGYIAATAAANGLTISTRDTSPFEAAGVKVINPWSR

Download         Length: 420 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9253.53 Da        Isoelectric Point: 8.9520

>AT267495 WP_003517203.1 NZ_CP115926:284296-284550 [Agrobacterium fabacearum]
MPAVTIRNLSEETHRALRVRAAHHGRSTEAEIRAIIEAAVRPPERIQLGSLLAAIGRDAELSNSDVEALQKSRDKTPAKP
MTFE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB F0LGD9

References