Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 259502..260145 Replicon chromosome
Accession NZ_CP115914
Organism Priestia filamentosa strain AZC66

Toxin (Protein)


Gene name pemK Uniprot ID A0A329EQQ9
Locus tag PGN40_RS01365 Protein ID WP_019395220.1
Coordinates 259795..260145 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag PGN40_RS01360 Protein ID WP_074842893.1
Coordinates 259502..259789 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGN40_RS01335 (PGN40_01335) 254658..255635 + 978 WP_120045889.1 UV DNA damage repair endonuclease UvsE -
PGN40_RS01340 (PGN40_01340) 255658..256245 - 588 WP_046218254.1 rhomboid family intramembrane serine protease -
PGN40_RS01345 (PGN40_01345) 256418..256774 + 357 WP_019395216.1 holo-ACP synthase -
PGN40_RS01350 (PGN40_01350) 256876..257883 + 1008 WP_046218253.1 outer membrane lipoprotein carrier protein LolA -
PGN40_RS01355 (PGN40_01355) 258080..259237 + 1158 WP_216700785.1 alanine racemase -
PGN40_RS01360 (PGN40_01360) 259502..259789 + 288 WP_074842893.1 ribbon-helix-helix protein, CopG family Antitoxin
PGN40_RS01365 (PGN40_01365) 259795..260145 + 351 WP_019395220.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PGN40_RS01370 (PGN40_01370) 260436..261269 + 834 WP_272541790.1 STAS domain-containing protein -
PGN40_RS01375 (PGN40_01375) 261272..261628 + 357 WP_019395222.1 STAS domain-containing protein -
PGN40_RS01380 (PGN40_01380) 261631..262032 + 402 WP_019395223.1 anti-sigma regulatory factor -
PGN40_RS01385 (PGN40_01385) 262044..263054 + 1011 WP_040059882.1 PP2C family protein-serine/threonine phosphatase -
PGN40_RS01390 (PGN40_01390) 263112..263444 + 333 WP_019395225.1 STAS domain-containing protein -
PGN40_RS01395 (PGN40_01395) 263441..263923 + 483 WP_019395226.1 anti-sigma B factor RsbW -
PGN40_RS01400 (PGN40_01400) 263889..264683 + 795 WP_019395227.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-48)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12919.04 Da        Isoelectric Point: 8.5368

>T267490 WP_019395220.1 NZ_CP115914:259795-260145 [Priestia filamentosa]
MVVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTVIVAAITAQIQKAKLPTHVEINAKKYGFERDSVILLEQV
RTIDKQRLTDKITHLDEEMMSKVDKALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10686.13 Da        Isoelectric Point: 5.7202

>AT267490 WP_074842893.1 NZ_CP115914:259502-259789 [Priestia filamentosa]
MLVSEASATMELLVRLPQHLVSELDAIAKQENSNRNDLINQAVKKFVDEKRNSSIRNNMRRGYMEMAKINLNIASEAFLA
EHEADNTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A329EQQ9

Antitoxin

Source ID Structure

References