Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 973660..974315 Replicon chromosome
Accession NZ_CP115904
Organism Neisseria gonorrhoeae strain MS11 HL-1-22

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag OK782_RS05075 Protein ID WP_003691083.1
Coordinates 973660..974079 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag OK782_RS05080 Protein ID WP_003688410.1
Coordinates 974079..974315 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK782_RS05055 (OK782_05055) 968894..970435 - 1542 WP_003688418.1 MDR family MFS transporter -
OK782_RS05060 (OK782_05060) 970583..971362 + 780 WP_003688416.1 (Fe-S)-binding protein -
OK782_RS05065 (OK782_05065) 971359..972060 + 702 WP_003688414.1 lactate utilization protein C -
OK782_RS05070 (OK782_05070) 972057..973511 + 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
OK782_RS05075 (OK782_05075) 973660..974079 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
OK782_RS05080 (OK782_05080) 974079..974315 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
OK782_RS05085 (OK782_05085) 974763..975341 - 579 WP_003688041.1 IS3 family transposase -
OK782_RS05090 (OK782_05090) 975346..975747 - 402 WP_020997337.1 helix-turn-helix domain-containing protein -
OK782_RS05095 (OK782_05095) 975986..976372 + 387 Protein_1000 IS110 family transposase -
OK782_RS05100 (OK782_05100) 976755..977645 - 891 WP_003688409.1 succinate--CoA ligase subunit alpha -
OK782_RS05105 (OK782_05105) 977656..978822 - 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
OK782_RS05110 (OK782_05110) 978894..979181 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T267483 WP_003691083.1 NZ_CP115904:c974079-973660 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT267483 WP_003688410.1 NZ_CP115904:c974315-974079 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References