Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 948900..949555 Replicon chromosome
Accession NZ_CP115904
Organism Neisseria gonorrhoeae strain MS11 HL-1-22

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag OK782_RS04945 Protein ID WP_003691083.1
Coordinates 948900..949319 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag OK782_RS04950 Protein ID WP_003688410.1
Coordinates 949319..949555 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK782_RS04925 (OK782_04925) 944134..945675 - 1542 WP_003688418.1 MDR family MFS transporter -
OK782_RS04930 (OK782_04930) 945823..946602 + 780 WP_003688416.1 (Fe-S)-binding protein -
OK782_RS04935 (OK782_04935) 946599..947300 + 702 WP_003688414.1 lactate utilization protein C -
OK782_RS04940 (OK782_04940) 947297..948751 + 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
OK782_RS04945 (OK782_04945) 948900..949319 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
OK782_RS04950 (OK782_04950) 949319..949555 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
OK782_RS04955 (OK782_04955) 950003..950581 - 579 WP_003688041.1 IS3 family transposase -
OK782_RS04960 (OK782_04960) 950586..950987 - 402 WP_020997337.1 helix-turn-helix domain-containing protein -
OK782_RS04965 (OK782_04965) 951170..951642 + 473 Protein_975 IS630 transposase-related protein -
OK782_RS04970 (OK782_04970) 951684..951854 - 171 WP_003688501.1 rubredoxin -
OK782_RS04975 (OK782_04975) 951987..953069 - 1083 WP_003688497.1 acyl-CoA dehydrogenase family protein -
OK782_RS04980 (OK782_04980) 953205..953753 - 549 WP_003695147.1 carboxymuconolactone decarboxylase family protein -
OK782_RS04985 (OK782_04985) 953893..954264 - 372 WP_003688492.1 DUF2628 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 949761..950006 245


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T267482 WP_003691083.1 NZ_CP115904:c949319-948900 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT267482 WP_003688410.1 NZ_CP115904:c949555-949319 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References