Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 153646..155189 Replicon plasmid p527820
Accession NZ_CP115896
Organism Kalamiella piersonii strain URMC-2103A041

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag PG877_RS19605 Protein ID WP_271153363.1
Coordinates 153646..154953 (-) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PG877_RS19610 Protein ID WP_120456481.1
Coordinates 154953..155189 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG877_RS19595 (PG877_19595) 149602..150003 - 402 WP_271153362.1 H-NS family nucleoid-associated regulatory protein -
PG877_RS19600 (PG877_19600) 151097..153262 + 2166 WP_271153410.1 ferric-rhodotorulic acid/ferric-coprogen receptor FhuE -
PG877_RS19605 (PG877_19605) 153646..154953 - 1308 WP_271153363.1 type II toxin-antitoxin system HipA family toxin Toxin
PG877_RS19610 (PG877_19610) 154953..155189 - 237 WP_120456481.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
PG877_RS19615 (PG877_19615) 155298..156620 - 1323 WP_179256413.1 glycoside hydrolase family 10 protein -
PG877_RS19620 (PG877_19620) 156706..157554 - 849 WP_120456476.1 VOC family protein -
PG877_RS19625 (PG877_19625) 157575..158711 - 1137 WP_271153411.1 amidohydrolase -
PG877_RS19630 (PG877_19630) 158708..159820 - 1113 WP_271153364.1 alkylhydroperoxidase domain protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN / pla 1..527820 527820


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-59)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 48034.47 Da        Isoelectric Point: 7.7813

>T267480 WP_271153363.1 NZ_CP115896:c154953-153646 [Kalamiella piersonii]
MDQLNAWMNGERVGTLTRQKNGAHIFQYEPGWLSNPLARPLSLSLPLQYPAIASASVINFFDNLLPDNPRVRERILNRYR
AKSMQPFDLLREVGRDSVGAVMLLPVEAAAPDLSVRYEPLDAARLEKILSAYQSDIPLGMIPEERDFRISVAGAQEKTAL
LKTPQGWAVPQGPTPTSHIIKLPIGEIKQPFATLDMCDSVENEYVCLALARELGFRVPDAAIITAGKLRALAVERFDRRW
SADGVRLLRLPQEDICQSLGLASATKYESDGGPGIAAIMSLLMGSSNALEDRDDFMKFQVFQWLLGATDGHAKNFSLYIE
RGGSYRLTPFYDILSAYPVLGGTGLNIRELKLAMGLTASKGKKVEIDKIFPRHFLATAASVRFSTERMAQILAFFAEAFP
AAVARVREQLPADIPPAIAEAIFSNALKMAERLSR

Download         Length: 1308 bp

>T267480 NZ_CP115896:c154953-153646 [Kalamiella piersonii]
ATGGATCAGCTCAACGCCTGGATGAACGGCGAACGCGTCGGCACGCTGACGCGCCAGAAAAATGGCGCGCATATCTTTCA
GTATGAGCCAGGCTGGCTGAGCAATCCGCTGGCGAGGCCGCTGTCGCTCTCGCTGCCGCTGCAGTACCCCGCTATCGCCT
CCGCCAGCGTCATCAACTTCTTCGATAACCTGCTGCCTGATAATCCTCGCGTCAGAGAGCGCATTCTTAACCGTTATCGG
GCGAAGTCAATGCAGCCGTTCGATCTGCTGCGGGAAGTAGGCCGCGACAGCGTCGGCGCGGTGATGCTGCTGCCCGTTGA
GGCCGCCGCGCCCGATCTCTCTGTACGTTATGAACCGCTCGACGCCGCGCGGCTGGAAAAAATACTTTCGGCGTACCAGA
GCGATATTCCGCTGGGGATGATCCCGGAAGAGCGTGACTTCCGCATTTCCGTCGCGGGCGCGCAGGAGAAAACCGCGCTG
CTGAAAACCCCTCAGGGCTGGGCCGTCCCTCAGGGGCCGACGCCCACGTCGCATATCATTAAGCTGCCGATCGGCGAAAT
TAAGCAGCCTTTCGCGACGCTCGATATGTGCGACAGCGTGGAAAACGAATATGTCTGCCTGGCGCTGGCGCGCGAGCTGG
GTTTTCGCGTGCCTGACGCCGCCATTATCACGGCCGGCAAGCTGCGCGCGCTGGCGGTAGAGCGATTTGACCGGCGCTGG
AGCGCTGACGGCGTCCGGCTGCTGCGCCTGCCGCAGGAGGATATTTGCCAGAGCCTCGGCCTCGCCTCCGCGACAAAATA
TGAATCTGACGGCGGGCCGGGCATTGCGGCGATCATGTCGCTGCTGATGGGCTCCAGCAATGCGCTGGAGGATCGCGACG
ATTTTATGAAGTTTCAGGTGTTCCAGTGGCTGCTCGGCGCGACCGACGGGCATGCGAAGAACTTTTCGCTCTATATCGAG
CGTGGTGGAAGCTACCGGTTGACGCCGTTCTACGACATTCTTTCCGCTTATCCGGTACTGGGCGGCACCGGCCTCAATAT
TCGCGAACTGAAGCTGGCGATGGGACTCACCGCGTCGAAGGGCAAGAAAGTGGAAATCGATAAAATCTTTCCGCGCCATT
TCCTCGCCACGGCGGCAAGCGTCCGCTTCTCCACCGAACGGATGGCGCAGATCCTCGCTTTCTTCGCGGAGGCGTTTCCG
GCCGCCGTGGCGCGCGTCAGGGAGCAACTGCCCGCCGATATCCCGCCCGCAATTGCCGAGGCTATTTTCAGTAACGCGCT
GAAAATGGCGGAGCGGCTTAGCCGGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9057.34 Da        Isoelectric Point: 10.2728

>AT267480 WP_120456481.1 NZ_CP115896:c155189-154953 [Kalamiella piersonii]
MIYSPQQLAHLIRLERQKRGWTQSDLARRVGIKQATVSNFENNPDKTTLTTLFKILQSLEQELVIQSKSTQSGKELEW

Download         Length: 237 bp

>AT267480 NZ_CP115896:c155189-154953 [Kalamiella piersonii]
ATGATCTACAGCCCACAACAGCTGGCCCATCTGATCAGGCTTGAACGGCAGAAGCGCGGCTGGACGCAGAGCGACCTGGC
GCGCCGGGTCGGCATCAAACAGGCCACCGTGTCGAACTTTGAAAATAATCCTGACAAGACTACGCTAACCACGCTGTTTA
AGATCCTGCAGTCGCTGGAGCAGGAGCTGGTAATTCAGAGTAAATCGACGCAGAGCGGCAAGGAGCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References