Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1397466..1398110 Replicon chromosome
Accession NZ_CP115895
Organism Kalamiella piersonii strain URMC-2103A041

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PG877_RS06675 Protein ID WP_271152916.1
Coordinates 1397934..1398110 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PG877_RS06670 Protein ID WP_120453379.1
Coordinates 1397466..1397870 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG877_RS06650 (PG877_06650) 1392484..1393278 + 795 WP_271152914.1 HPr family phosphocarrier protein -
PG877_RS06655 (PG877_06655) 1393391..1394746 + 1356 WP_120453375.1 GntP family transporter -
PG877_RS06660 (PG877_06660) 1394846..1395871 + 1026 WP_271152915.1 Gfo/Idh/MocA family oxidoreductase -
PG877_RS06665 (PG877_06665) 1395899..1397329 - 1431 WP_179256388.1 exodeoxyribonuclease I -
PG877_RS06670 (PG877_06670) 1397466..1397870 - 405 WP_120453379.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PG877_RS06675 (PG877_06675) 1397934..1398110 - 177 WP_271152916.1 type II toxin-antitoxin system HicA family toxin Toxin
PG877_RS06680 (PG877_06680) 1398167..1398313 - 147 WP_271152917.1 hypothetical protein -
PG877_RS06685 (PG877_06685) 1398378..1399541 + 1164 WP_179256389.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
PG877_RS06690 (PG877_06690) 1399576..1400793 - 1218 WP_271152918.1 cytochrome c -
PG877_RS06695 (PG877_06695) 1400790..1402553 - 1764 WP_120453385.1 GMC family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-56)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6760.10 Da        Isoelectric Point: 11.1683

>T267474 WP_271152916.1 NZ_CP115895:c1398110-1397934 [Kalamiella piersonii]
MSSKEVMKLLREHGWVFVRIRGSHHLFVKPGKNYHITLPHPEKDLAAGTLRKIMKLIN

Download         Length: 177 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14798.73 Da        Isoelectric Point: 4.5232

>AT267474 WP_120453379.1 NZ_CP115895:c1397870-1397466 [Kalamiella piersonii]
MRFPVYLHQTDSGSYSGFVPDIEGCFFAGETVDDAILDAGAAIDIHLEALAESGMPVPHTKGMAFYLESDECQGGIWAVI
DIDISKYEGKAVKLNITLPQSLLTRIDRFVESHQEFSSRSGFLAELARRELAKR

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References