Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2171134..2171648 Replicon chromosome
Accession NZ_CP115887
Organism Staphylococcus aureus strain C308

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag PCM89_RS10765 Protein ID WP_000581792.1
Coordinates 2171134..2171343 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag PCM89_RS10770 Protein ID WP_000138928.1
Coordinates 2171355..2171648 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PCM89_RS10745 (2166642) 2166642..2168000 - 1359 WP_000611469.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
PCM89_RS10750 (2168015) 2168015..2169085 - 1071 WP_000159632.1 D-alanine--D-alanine ligase -
PCM89_RS10755 (2169403) 2169403..2170605 + 1203 WP_001109944.1 FtsW/RodA/SpoVE family cell cycle protein -
PCM89_RS10760 (2170869) 2170869..2171006 - 138 WP_000828354.1 Lmo0850 family protein -
PCM89_RS10765 (2171134) 2171134..2171343 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
PCM89_RS10770 (2171355) 2171355..2171648 - 294 WP_000138928.1 copper-sensing transcriptional repressor CsoR Antitoxin
PCM89_RS10775 (2171814) 2171814..2173298 + 1485 WP_000571551.1 cardiolipin synthase -
PCM89_RS10780 (2173326) 2173326..2173973 + 648 WP_001187617.1 HD domain-containing protein -
PCM89_RS10785 (2174451) 2174451..2175323 - 873 WP_000725802.1 membrane protein insertase YidC -
PCM89_RS10790 (2175409) 2175409..2176050 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T267468 WP_000581792.1 NZ_CP115887:c2171343-2171134 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11184.82 Da        Isoelectric Point: 6.2243

>AT267468 WP_000138928.1 NZ_CP115887:c2171648-2171355 [Staphylococcus aureus]
MTEQDIAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure

References