Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2151378..2151907 Replicon chromosome
Accession NZ_CP115887
Organism Staphylococcus aureus strain C308

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PCM89_RS10675 Protein ID WP_000621175.1
Coordinates 2151378..2151740 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag PCM89_RS10680 Protein ID WP_000948330.1
Coordinates 2151737..2151907 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PCM89_RS10655 (2148356) 2148356..2149126 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
PCM89_RS10660 (2149101) 2149101..2149580 - 480 WP_001190825.1 anti-sigma B factor RsbW -
PCM89_RS10665 (2149582) 2149582..2149908 - 327 WP_001052491.1 anti-sigma factor antagonist -
PCM89_RS10670 (2150028) 2150028..2151029 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
PCM89_RS10675 (2151378) 2151378..2151740 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PCM89_RS10680 (2151737) 2151737..2151907 - 171 WP_000948330.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PCM89_RS10685 (2151992) 2151992..2153140 - 1149 WP_001281141.1 alanine racemase -
PCM89_RS10690 (2153206) 2153206..2153565 - 360 WP_000581193.1 holo-ACP synthase -
PCM89_RS10695 (2153569) 2153569..2154060 - 492 WP_001205918.1 PH domain-containing protein -
PCM89_RS10700 (2154047) 2154047..2155630 - 1584 WP_001294624.1 PH domain-containing protein -
PCM89_RS10705 (2155623) 2155623..2156102 - 480 WP_001287080.1 hypothetical protein -
PCM89_RS10710 (2156311) 2156311..2156871 - 561 WP_001092400.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T267467 WP_000621175.1 NZ_CP115887:c2151740-2151378 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6237.75 Da        Isoelectric Point: 3.8305

>AT267467 WP_000948330.1 NZ_CP115887:c2151907-2151737 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNESYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References