Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1935747..1936523 Replicon chromosome
Accession NZ_CP115887
Organism Staphylococcus aureus strain C308

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag PCM89_RS09325 Protein ID WP_000031112.1
Coordinates 1935747..1935899 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag PCM89_RS09330 Protein ID WP_001251224.1
Coordinates 1935924..1936523 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PCM89_RS09310 (1931653) 1931653..1932474 + 822 WP_000669382.1 RluA family pseudouridine synthase -
PCM89_RS09315 (1932936) 1932936..1934321 - 1386 WP_000116232.1 class II fumarate hydratase -
PCM89_RS09320 (1934517) 1934517..1934912 - 396 WP_000901023.1 hypothetical protein -
PCM89_RS09325 (1935747) 1935747..1935899 - 153 WP_000031112.1 SAS053 family protein Toxin
PCM89_RS09330 (1935924) 1935924..1936523 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
PCM89_RS09335 (1936682) 1936682..1937152 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
PCM89_RS09340 (1937157) 1937157..1938284 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
PCM89_RS09345 (1938434) 1938434..1939156 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
PCM89_RS09350 (1939149) 1939149..1940606 - 1458 WP_000649910.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5966.31 Da        Isoelectric Point: 3.8962

>T267464 WP_000031112.1 NZ_CP115887:c1935899-1935747 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELSKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT267464 WP_001251224.1 NZ_CP115887:c1936523-1935924 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References