Detailed information of TA system TA026746

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1174182..1174991
• Replicon: chromosome
• Accession: NC_017353
• Organism: Staphylococcus lugdunensis N920143

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: SLUG_RS12935
• Protein ID: WP_002458758.1
• Coordinates: 1174821..1174991 (+)
• Length: 57 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A853V5R2
• Locus tag: SLUG_RS05615
• Protein ID: WP_002458757.1
• Coordinates: 1174182..1174781 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SLUG_RS05595	1169769..1171226	+	1458	WP_002477974.1	ABC transporter substrate-binding protein/permease	-
SLUG_RS05600	1171219..1171944	+	726	WP_002477975.1	amino acid ABC transporter ATP-binding protein	-
SLUG_RS05605	1172402..1173544	+	1143	WP_141760444.1	tRNA epoxyqueuosine(34) reductase QueG	-
SLUG_RS05610	1173546..1174016	+	471	WP_002458756.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
SLUG_RS05615	1174182..1174781	+	600	WP_002458757.1	glucosamine-6-phosphate isomerase	Antitoxin
SLUG_RS12935	1174821..1174991	+	171	WP_002458758.1	hypothetical protein	Toxin
SLUG_RS05620	1175165..1175560	+	396	WP_002458759.1	hypothetical protein	-
SLUG_RS05625	1175688..1177073	+	1386	WP_002477977.1	class II fumarate hydratase	-
SLUG_RS05630	1177138..1177974	-	837	WP_002477978.1	RluA family pseudouridine synthase	-
SLUG_RS05635	1178142..1179254	+	1113	WP_002477979.1	GAF domain-containing sensor histidine kinase	-
SLUG_RS05640	1179276..1179899	+	624	WP_002477980.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (131-195)

Sequences

Toxin

Protein

• Length: 57 a.a.
• Molecular weight: 6565.10 Da
• Isoelectric Point: 4.6723

>T26746 WP_002458758.1 NC_017353:1174821-1174991 [Staphylococcus lugdunensis N920143]
MSKEKKSRLNYHEEENAMVENLEDLKELGKEMEHISEKNDEEKVNQSHDTSKSSNS

Nucleotide

• Length: 171 bp

>T26746 NC_017353:1174821-1174991 [Staphylococcus lugdunensis N920143]
ATGTCAAAAGAAAAAAAGAGTCGTTTAAATTATCATGAGGAAGAGAATGCGATGGTTGAAAATTTAGAAGACTTAAAAGA
GCTGGGCAAAGAAATGGAACACATCTCAGAGAAAAATGACGAAGAAAAAGTTAATCAATCGCATGATACATCAAAGTCTT
CAAATTCATAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22619.51 Da
• Isoelectric Point: 4.9539

>AT26746 WP_002458757.1 NC_017353:1174182-1174781 [Staphylococcus lugdunensis N920143]
MAMNFKVFENKDQVAEYSADIIRKQFNNNPTTIAGFHLNKEASPVLDMLKKNVDQHAVDFSQINILDYDQNQEYFKALGV
PESQIYPISYDQDAEAFISDKIKTKDNKGKLILQVASIDDQGNLNISLRQGLLNAREIILVITGHNKKEVVEKLYNENGK
SNFEPADLKAHRMVTVILDEAAAEGLPEDVRHYFTDRFA

Nucleotide

• Length: 600 bp

>AT26746 NC_017353:1174182-1174781 [Staphylococcus lugdunensis N920143]
ATGGCAATGAACTTTAAAGTATTTGAAAATAAAGATCAAGTTGCAGAGTATTCAGCAGATATCATTAGAAAACAATTTAA
CAATAATCCTACTACAATTGCTGGATTTCATTTAAACAAAGAGGCATCACCAGTACTTGATATGCTTAAAAAGAATGTTG
ACCAACATGCGGTTGACTTCAGCCAAATTAACATTCTTGACTATGATCAAAATCAAGAATATTTCAAAGCGCTGGGGGTT
CCTGAGAGTCAAATTTATCCTATCTCATACGATCAAGATGCTGAAGCGTTTATCTCTGATAAAATCAAAACAAAAGATAA
TAAAGGGAAACTAATATTACAAGTAGCTTCAATTGATGATCAAGGAAACCTTAATATCAGTCTACGTCAAGGATTGTTAA
ATGCTAGAGAAATTATCTTAGTCATTACAGGACATAATAAAAAAGAAGTAGTAGAAAAACTGTATAATGAAAATGGAAAA
TCTAATTTTGAACCTGCTGATTTAAAAGCACATCGTATGGTAACGGTTATTTTAGACGAAGCGGCAGCTGAAGGTTTGCC
AGAAGATGTACGTCATTACTTTACTGATCGGTTTGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A853V5R2