267457

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 829723..830200 Replicon chromosome
Accession NZ_CP115887
Organism Staphylococcus aureus strain C308

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag PCM89_RS03855 Protein ID WP_000052076.1
Coordinates 829723..829911 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag PCM89_RS03860 Protein ID WP_001059690.1
Coordinates 829940..830200 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PCM89_RS03825 (825713) 825713..826234 + 522 WP_000824488.1 hypothetical protein -
PCM89_RS03830 (826575) 826575..827261 + 687 WP_001670297.1 thermonuclease family protein -
PCM89_RS03835 (827618) 827618..827818 + 201 WP_001059082.1 cold-shock protein -
PCM89_RS03840 (828314) 828314..828532 - 219 WP_000005876.1 hypothetical protein -
PCM89_RS03845 (828594) 828594..828878 - 285 WP_001004395.1 hypothetical protein -
PCM89_RS03850 (828966) 828966..829535 - 570 WP_001106646.1 lipoprotein N-acylation protein LnsA -
PCM89_RS03855 (829723) 829723..829911 - 189 WP_000052076.1 hypothetical protein Toxin
PCM89_RS03860 (829940) 829940..830200 - 261 WP_001059690.1 hypothetical protein Antitoxin
PCM89_RS03865 (830540) 830540..830743 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
PCM89_RS03870 (830740) 830740..830976 - 237 WP_000368687.1 hypothetical protein -
PCM89_RS03875 (831201) 831201..831782 + 582 WP_001140696.1 histidine phosphatase family protein -
PCM89_RS03880 (831855) 831855..832472 - 618 WP_000255559.1 LysE/ArgO family amino acid transporter -
PCM89_RS03885 (832625) 832625..833119 - 495 WP_000590539.1 GNAT family N-acetyltransferase -
PCM89_RS03890 (833518) 833518..833940 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
PCM89_RS03895 (834088) 834088..834804 + 717 WP_000150015.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T267457 WP_000052076.1 NZ_CP115887:c829911-829723 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT267457 WP_001059690.1 NZ_CP115887:c830200-829940 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References